Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-118-2 | CAS number: 103-50-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Test protocol and results insufficent reported for evaluation
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Study of artificial flavoring substances for mutagenicity in the Salmonella/Microsome, BASC and micronucleus tests
- Author:
- Wild D.K., Gocke M., and Eckhardt K.
- Year:
- 1 983
- Bibliographic source:
- Food Chem. Toxicol., 21, 707-719.
- Reference Type:
- other: Peer-review database
- Title:
- No information
- Bibliographic source:
- Toxline, [URL]: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?TOXLINE, CAS n° 103-50-4, toxline abstract n° 27.
Materials and methods
- Principles of method if other than guideline:
- Several compounds incl. dibenzyl ether used as artifical flavouring substances were studied for mutagenic properties in a micronuleus test on mouse bone marrow.
- GLP compliance:
- not specified
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- Dibenzyl ether
- EC Number:
- 203-118-2
- EC Name:
- Dibenzyl ether
- Cas Number:
- 103-50-4
- Molecular formula:
- C14H14O
- IUPAC Name:
- [(benzyloxy)methyl]benzene
- Details on test material:
- Dibenzyl ether was supplied by EGA Chemie, Steinheim
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- No data
- Details on exposure:
- No data
- Duration of treatment / exposure:
- Mice were killed at 30 hr
- Frequency of treatment:
- Twice (0 and 24 hr)
- Post exposure period:
- None
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 400, 700, or 1000 mg/Kg
Basis:
nominal conc.
- No. of animals per sex per dose:
- Four mice per dose
- Control animals:
- yes, concurrent vehicle
- Positive control(s):
- no data
Examinations
- Tissues and cell types examined:
- mouse bone marrow
- Details of tissue and slide preparation:
- no data
- Evaluation criteria:
- no data
- Statistics:
- no data
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Additional information on results:
- no data
Any other information on results incl. tables
All mice trated with 0 (vehicle), 400, 700 or 1000 mg/kg bw survived. At a dose of 0 mg/kg bw 1.8 micronuleated polychromatic erythrocytes /1000 PE, at a dose of 400 mg/kg bw 3.0 micronuleated polychromatic erythrocytes /1000 PE, at a dose of 700 mg/kg bw
3.7 micronuleated polychromatic erythrocytes /1000 PE and at a dose of 1000 mg/kg bw 2.0 micronuleated polychromatic erythrocytes /1000 PE were found.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: negative
- Executive summary:
Male and female NMRI mice (10 -14 wks old) were treated twice (at 0 and 24 hr) with dibenzyl ether in olive oil. In each dose group 4 mice were treated with either 0, 400, 700, or 1000 mg/kg bw). The mice were killed and bone-marrow smears were prepared 30 hr after treatment. The smears were stained and scored. The mean number of micronucleated polychromatic erytrocytes/1000 polychromatic erytrocytes were determined. Dibenzyl ether was negative in this test.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.