Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-106-7 | CAS number: 7439-97-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study reliable with restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Lung and blood superoxide dismutase activity in mercury vapor exposed rats: effect of N-acetylcysteine treatment
- Author:
- Livardjani, F. et al.
- Year:
- 1 991
- Bibliographic source:
- Toxicology, 66, 289 - 295.
Materials and methods
- Principles of method if other than guideline:
- Rats were exposed whole body to mercury vapours (30 mg/m^3) for either 1 or 2 h.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Mercury
- EC Number:
- 231-106-7
- EC Name:
- Mercury
- Cas Number:
- 7439-97-6
- Molecular formula:
- Hg
- IUPAC Name:
- mercury
- Details on test material:
- - Name of test material (as cited in study report): mercury (vapour form administered)
No further information on the test material was stated.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: approx. 150 g.
- Housing: in a metabolic box.
No further information on the test animals was stated.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
Rats were maintained in a metabolic box which was placed in a hermetic chamber (0.33 cm^3). Mercury vapours were introduced by a pump (3 l/min) from heated mercury contained in a flask heated outside the chamber. The air was continuously recycled and the temperature maintained at 22 +/- 0.5 °C.
TEST ATMOSPHERE
In the circulating air, Hg concentration was measured in 10-ml samples, within 5 min of initial animal exposure, by atomic absorption spectrometry (spectrometer IL 152) according to Heimbuerger et al. (Heimburger, R., Liverdjani, F., and Leroy, M.J. (1986). Analyse du mercure par spectrométrie d'absorption atomique en vapeur froide. Analysis, 14, 173.).
No further information on the inhalation exposure was stated. - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- see "Details on inhalation exposure" above
- Duration of exposure:
- 1 - 2
- Remarks on duration:
- Group 1 was exposed for 1 h and group 2 for 2 h.
- Concentrations:
- Two types of Hg exposure:
Group 1: 26.6 +/- 4.7 mg Hg per m^3
Group 2. 27.0 +/- 3.8 mg Hg per m^3 - No. of animals per sex per dose:
- 32 male rats
- Control animals:
- not specified
- Details on study design:
- The animals were sacrified 1, 2, 3, 4, 5, 6, 7 and 15 days after Hg exposure.
Observations of clinical signs were conducted. The animals either died spontaneously or were sacrified after anesthesia by i.p. injection of 350 mg/kg of ketamine. Blood was taken by cardiac puncture, the lung was excised and frozen at -70 °C. Mercury measurements were made in the blood and the lung samples. Also, superoxide dismutase activity was measured in the blood and the lung samples.
No further information on the study design was stated. - Statistics:
- no data
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 26.6 mg/m³ air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Remarks on result:
- other: All animals of group 1 survived until scheduled sacrifice. (Standard deviation: +/- 4.7 mg/m^3).
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- < 27 mg/m³ air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 2 h
- Remarks on result:
- other: 20 of 32 animals of Group 2 died by asphyxia before scheduled sacrifice. No animals were alive 5 days after intoxication. (Standard deviation: 3.8 mg/m^3).
- Mortality:
- No animals of group 1 died in advance of sacrifice.
20 of 32 animals of Group 2 died by asphyxia before the sacrifice time. No animals were living more than 5 days after intoxication. - Clinical signs:
- other: During Hg exposure, the animals of Group 1 did not show breathing difficulties. The animals of Group 2 showed dyspnoea.
- Body weight:
- The animals of Group 2 had also an important weight loss ranging from 15 to 25 %.
- Gross pathology:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- very toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Metalic mercury is classified according to the EC Regulation No. 1272/2008 and subsequent regulations as fatal if inhaled.
According to the the criteria specified by Directive 67/548/EEC and subsequent regulations, the test item is very toxic by inhalation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.