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Diss Factsheets
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EC number: 438-390-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994-10-27 to 1994-11-17
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable without restrictions because the study was conducted according to OECD 401 and other guidelines and was GLP compliant.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Details on test material:
- This substance is very similar with regard to health endpoints to the substance being registered.
- Name of test material (as cited in study report): Alkane 4
- Substance type: Poly alpha olefin (1-dodecene trimer, hydrogenated)
- Physical state: Liquid
- Analytical purity: Not reported
- Lot/batch No.: C1527-04-4
- Stability under test conditions: Not reported
- Storage condition of test material: Room temperature
- Other: Clear colourless liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (U.K.) Ltd.
- Age at study initiation: 8 weeks
- Weight at study initiation: Male: 209-224 grams; Female: 200-213 grams
- Fasting period before study: Overnight prior to dosing and 2 hours post dosing
- Housing: Groups of 5 in grid bottom polypropylene cages
- Diet (e.g. ad libitum): Rat and Mouse Expanded Diet No. 1 (Special Diet Services Ltd, U.K.) ad libitum except during fasting
- Water (e.g. ad libitum): ad libitum
- Acclimation period: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-21°C
- Humidity (%): 49-54%
- Air changes (per hr): 15 per hr
- Photoperiod (hrs dark / hrs light): 12 hrs dark/12 hrs light
IN-LIFE DATES: From: 1994-10-27 To: 1994-11-17
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 6.14 mL/kg (5000 mg/kg); volume calculated based on individual body weight
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 5/sex/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical signs and mortality: 1, 2.5 and 4 hours post dosing and once daily thereafter for 14 days; Body weight: Days 0, 7, and 14
- Necropsy of survivors performed: Yes
- Other examinations performed: Clinical signs, body weight - Statistics:
- Not reported
Results and discussion
- Preliminary study:
- No deaths or clinical signs of toxicity were observed in male or female rats. No treatment-related abnormalities were observed at necroscopy.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Remarks on result:
- other: Based on lack of adverse clinical toxicity and mortality
- Mortality:
- There was no mortality observed in either male or female rats administered 1-dodecene, trimer, hydrogenated orally at 5000 mg/kg.
- Clinical signs:
- There were no signs of systemic toxicity observed at the 5000 mg/kg dose level.
- Body weight:
- Body weight gain was not adversely impacted by oral administration of the test material.
- Gross pathology:
- Gross necroscopy revealed no remarkable findings in either male or female rats.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Acute oral LD50 >5000 mg/kg bw Criteria used for interpretation of results: EU
- Conclusions:
- Based on the lack of adverse systemic effects and mortality, the acute oral LD50 for 1-dodecene, trime, hydrogenatedr is >5000 mg/kg.
- Executive summary:
In an acute oral toxicity study, 1 group of five fasted Sprague-Dawley rats/sex were given a single oral dose of 1 -dodecene, trimer (undiluted) at a dose of 5000 mg/kg bw and observed for 14 days.
There was no mortality or clinical signs of toxicity observed. Body weight did not appear to be affected by treatment. There were no abnormalities observed at necropsy. Based on these results, the oral LD50 for 1 -dodecene, trimer is greater than 5000 mg/kg in rats.
This study received a Klimisch score of 1 and is classified as reliable without restrictions because the study was conducted according to OECD 401 guidelines and other guidelines and was GLP compliant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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