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EC number: 436-120-9 | CAS number: 99627-05-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June 19, 2000 - August 16, 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- July 1992
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3,4,5-trifluorophenol
- EC Number:
- 436-120-9
- EC Name:
- 3,4,5-trifluorophenol
- Cas Number:
- 99627-05-1
- Molecular formula:
- C6H3F3O
- IUPAC Name:
- 3,4,5-trifluorophenol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- Crl:KBL(NZW)BR
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Wiga GmbH, KiBlegg
- Age at study initiation: about 18 weeks
- Weight at study initiation: 3.39 kg
- Housing: special rabbit cages (manufacturer: Becker; type K99/30 KU, floor area about 5400 cm2, a shelter with an integrated sitting board of about 1820 cm2; overall height: 60 cm;) with plastic grids placed on mobile racks
- Diet: ad libitum, diet for rabbits No. 814 and No. 5697, Eberle Nafag
- Water: ad libitum, tap water
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 to 21
- Humidity (%): 62 to 73
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Remarks:
- Aqua pro injectione
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
0.5 g of the test material was mixed with some drops of Aqua pro injectione and spread onto a patch of about 6 cm2. The patch was fastened to the left side of the animal's back and kept in place by a self-adhesive fabric (Fixomull® stretch, Beiersdorf).
- Amount(s) applied (volume or weight with unit): 0.5 g - Duration of treatment / exposure:
- 4 hours
- Number of animals:
- 1
- Details on study design:
- TEST SITE
- Area of exposure: animal's back and kept in place by a self-adhesive fabric (Fixomull® stretch, Beiersdorf).
REMOVAL OF TEST SUBSTANCE
- Washing: not specified
SCORING SYSTEM:
- Method of calculation: according to DRAIZE
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- After a single application to the intact dorsal skin of a rabbit, for a 4 hours period of exposure under semiocclusive conditions, necrosis (Erythema and eschar formation: score 4) of the skin was observed in the treated area. Therefore the study was finished. No signs of pain or itching were detected.
- Other effects:
- -Results of Pre-test:
The test material was screened for its irritating potential with the hen's egg test on the chorioallantoic membrane (HET-CAM). Fertile hen eggs on day 10 of incubation provided the test system. The egg shell was entered above the air cell by a dentist's rotary and then pared off. The shell with attached outer membrane and inner egg membrane was carefully opened. After the membrane had been moistened with isotonic sodium chloride solution, it was removed to expose the chorioallantoic membrane (CAM) of the fertilized egg, which lies immediately below. The chorioallantoic membrane (CAM) of fertilized and incubated hen eggs provides a suitable model for membranes with an intact and functional vascular system. The CAM has no nerve fibers in the early stages of development and is, thus, regarded as being insensitive to pain.In this model the cumulative irritation score was 8.84. This revealed a moderate irritating potential and the animal study was started with one rabbit.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- The test item is regarded as corrosive to the skin.
- Executive summary:
A study according to OECD TG 404 was performed to determine irritative/corrosive properties of the test item to the skin. The study was started with one rabbit. For the primary skin irritation, the test item was mixed with some drops of Aqua pro injectione to ensure good contact to the skin. Afterwards the test material was spread onto patches and applied to the intact skin of one previously shaven rabbit for a 4 hours period under semiocclusive conditions. The first examination of the treated skin sites followed after removal of the patches.
Strong local changes were seen, the study was finished and the rabbit was sacrificed. Necrosis was seen at the application site directly after removal of the patches. No signs of pain or itching could be observed.
Therefore, the test item is regarded as corrosive to the skin.
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