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Diss Factsheets
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EC number: 237-198-5 | CAS number: 13684-56-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012-10-18 to 2012-12-06
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Deviations:
- no
- Principles of method if other than guideline:
- UV/VIS — absorption spectrum of the dissociated and undissociated forms of the chemical substance. In the particular case, described in the OECD Test Guideline 112, the test item is behaving as an acid or base, and the determination is most conveniently done by determining the different extinction coefficients (absorption) of ionised and unionised forms of the test item and the pH of the solution.
Dissociation is the reversible splitting into two or more chemical species which may be ionic by
RX <-> R+ + X-
The concentration equilibrium constant governing the reaction is
K= [R+][X-] /[ RX] - GLP compliance:
- yes
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- 0
- Temp.:
- 23 °C
- Remarks on result:
- not determinable
- Conclusions:
- The result is acceptable. No dissociation constant pKa was found in aqueous solution of Desmedipham (AE B038107), pure substance, in the pH-range of 2 < pH < 6.
At pH values above pH 7 a rapid hydrolysis of Desmedipham takes place. - Executive summary:
Test Guideline: Based on OECD Test Guideline 112, US EPA Product Properties Test Guideline OCSPP 830.7370
The dissociation constant of Desmedipham was examined using a spectrophotometric method based on the OECD-Guideline 112 and the US EPA Product Properties Test Guideline OCSPP 830.7370.
Due to the lack of stability above pH 7, the UV/VIS spectra of the test item were recorded at pH 1.95 and pH 5.82 at room temperature (approx. 23°C).
The UV/VIS spectra were almost congruent, taking the UV absorption of aqueous hydrochloric acid into account. No relevant difference was found between the UV/VIS absorption at the examined pH values.
Result:
No dissociation constant pKa was found in aqueous solution of Desmedipham, pure substance, in the pH-range of 2 < pH < 6. At pH values above pH 7 a rapid hydrolysis of Desmedipham takes place
This finding corresponds to the result that Desmedipham, pure substance, shows no acidic or basic properties in the range of approximately 2 < pKa < 6.
Reference
Table 2: Details of experiment A
Experiment | Volume and concentration of added I-ICI | Resulting pH value |
| 5.82 | |
0.5 mc- 1.0 mol/L | 1.95 |
An overlay plot of the UV/VlS-spectra is given in Section 8, Figure 1
This means (according to Section 4.2) that no dissociation equilibrium occurred for Desmedipham, pure substance in the pH range 2 < pH < 6.
This result is equivalent to the conclusion that Desmedipham, pure substance, showed no pKa value in the range 2 < pKa < 6.
Description of key information
No dissociation constant pKa was found in aqueous solution of Desmedipham, pure substance, in the pH-range of 2 < pH < 6. At pH values above pH 7 a rapid hydrolysis of Desmedipham takes place
Key value for chemical safety assessment
Additional information
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