Registration Dossier
Registration Dossier
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EC number: 600-704-3 | CAS number: 10597-60-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 2010
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Version / remarks:
- study was a publication but used OECD 429 as guiding protocol
- Deviations:
- not specified
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- 4-(2-hydroxyethyl)benzene-1,2-diol
- EC Number:
- 600-704-3
- Cas Number:
- 10597-60-1
- Molecular formula:
- C8H10O3
- IUPAC Name:
- 4-(2-hydroxyethyl)benzene-1,2-diol
1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- other: EtOH
- Concentration:
- 100%
- Details on study design:
- 0.01,0.1, 0.5 and 5.0 % concentration of the test substance
- Positive control substance(s):
- not specified
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Key result
- Parameter:
- EC3
- Value:
- ca. 0.6
- Parameter:
- SI
- Value:
- ca. 1.4
- Test group / Remarks:
- 0.1
- Parameter:
- SI
- Value:
- ca. 2.6
- Test group / Remarks:
- 0.5
- Parameter:
- SI
- Value:
- ca. 18.6
- Test group / Remarks:
- 5.0
Applicant's summary and conclusion
- Interpretation of results:
- Category 1A (indication of significant skin sensitising potential) based on GHS criteria
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