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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Remarks:
- Read across data
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is taken from a secondary source
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Acute oral toxicity study in rats
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- N-(3-(trimethoxysilyl)propyl)ethylenediamine
- EC Number:
- 217-164-6
- EC Name:
- N-(3-(trimethoxysilyl)propyl)ethylenediamine
- Cas Number:
- 1760-24-3
- Molecular formula:
- C8H22N2O3Si
- IUPAC Name:
- (2-Aminoethyl)(3-(trimethoxysilyl)propyl)amine
Constituent 1
- Specific details on test material used for the study:
- Not specified
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Rationale for alternative/additional species to rat (if applicable)
- Source: Lesser Ketones Manufacturing Association Leesburg, VA
- Females (if applicable) nulliparous and non-pregnant: [yes/no] No data available
- Rationale for use of males (if applicable) No data available
- Age at study initiation:e No data available
- Weight at study initiation: No data available
- Fasting period before study: No data available
- Housing:No data available
- Historical data:No data available
- Diet (e.g. ad libitum): No data available
- Water (e.g. ad libitum):No data available
- Acclimation period:No data available
- Microbiological status when knownNo data available
- Method of randomisation in assigning animals to test and control groups No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%): No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: No data available
- Amount of vehicle (if gavage): No data available
- Justification for choice of vehicle: No data available
- Lot/batch no. (if required): No data available
- Purity: No data available
Doses per time period: One
Post dose observation period: 72 hours
MAXIMUM DOSE VOLUME APPLIED: No data available
DOSAGE PREPARATION (if unusual): No data available
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: - Doses:
- 0.84, 1.04, 1.35, 1.75, 2.28, 2.96, 3.85 ml/kg bw
- No. of animals per sex per dose:
- 5animal /sex/dose
- Control animals:
- no
- Details on study design:
- Not specified
- Statistics:
- Not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1.68 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1.52 - <= 1.86
- Remarks on result:
- other: limited time to observe
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2.25 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1.91 - <= 2.66
- Remarks on result:
- other: limited time to observe
- Mortality:
- In females LD 50 value found at 1.68ml/kg bw while in males the LD50 value was found to be 2.25ml/kg bw
- Clinical signs:
- other:
- Body weight:
- other body weight observations
- Gross pathology:
- Necropsy findings, including quantities, severity, and the number of animals affected, were as follows: It was noted that red-colored sores and apoplexy occurred in the gastric glandular, and the intestine wall began to discolor. Values [LD50 or LC50] with confidence limits when calculated: Males received 2.25 ml/kg body weight with 95% confidence limits and females received 1.68 ml/kg body weight with 95% confidence limits.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not Classified
- Conclusions:
The oral LD50 values were identified as 2.25 ml/kg bw in males and 1.68 ml/kg bw in females according to a relatively limited citation of a study without guidelines or good laboratory practices compliance and observation apparently only for 72 hours.- Executive summary:
In accordance with guideline 401, a test of acute oral toxicity of 1,2-ethanediamine, N-[3-(trimethoxysilyl)propyl] (CAS number: 1760-24-3) was conducted using Rat of Wistar species at various dose levels 0.84, 1.04, 1.35, 1.75, 2.28, 2.96, 3.85 ml/kg bw.
The test sample was administered to all animals in five species/sex/doses. Clinical findings reviles sedation, diarrhea, and watery eyes were observed within the 2.96 and 3.85 ml/kg groups.
Necropsy findings, including quantities, severity, and therefore the number of animals affected, were as follows: It was noted that red-colored sores and apoplexy occurred within the gastric glandular, and therefore the intestine wall began to discolor. Values [LD50 or LC50] confidently limits when calculated: Males received 2.25 ml/kg weight with 95% confidence limits and females received 1.68 ml/kg weight with 95% confidence limits. No mortality was observed.
The LD50 value of the test sample was 2.25 ml/kg bw for males and 1.68 ml/kg bw for females. Hence the test chemical cannot be classified according to CLP Criteria for classification.
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