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EC number: 267-012-8 | CAS number: 67762-34-9 This substance is identified by SDA Substance Name: C8-C18 and C18 unsaturated alkyl carboxylic acid zinc salt and SDA Reporting Number: 01-006-09.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 022
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Zinc dioctanoate
- EC Number:
- 209-156-6
- EC Name:
- Zinc dioctanoate
- Cas Number:
- 557-09-5
- Molecular formula:
- C16H30O4Zn
- IUPAC Name:
- zinc(II) octanoate
- Reference substance name:
- Zinc decanoate
- EC Number:
- 235-909-3
- EC Name:
- Zinc decanoate
- Molecular formula:
- C10H20O2.1/2Zn
- IUPAC Name:
- zinc(II) decanoate
- Reference substance name:
- Zinc dilaurate
- EC Number:
- 219-518-5
- EC Name:
- Zinc dilaurate
- Cas Number:
- 2452-01-9
- Molecular formula:
- C12H24O2.1/2Zn
- IUPAC Name:
- zinc(II) dodecanoate
- Reference substance name:
- Zinc dimyristate
- EC Number:
- 240-369-7
- EC Name:
- Zinc dimyristate
- Cas Number:
- 16260-27-8
- Molecular formula:
- C28H54O4Zn
- IUPAC Name:
- zinc(II) tetradecanoate
- Reference substance name:
- Zinc dipalmitate
- EC Number:
- 225-652-5
- EC Name:
- Zinc dipalmitate
- Cas Number:
- 4991-47-3
- Molecular formula:
- C16H32O2.1/2Zn
- IUPAC Name:
- zinc(II) hexadecanoate
- Reference substance name:
- Zinc distearate
- EC Number:
- 209-151-9
- EC Name:
- Zinc distearate
- Cas Number:
- 557-05-1
- Molecular formula:
- C18H36O2.1/2Zn
- IUPAC Name:
- zinc(II) octadecanoate
- Reference substance name:
- Zinc dioleate
- EC Number:
- 209-154-5
- EC Name:
- Zinc dioleate
- Cas Number:
- 557-07-3
- Molecular formula:
- C18H34O2.1/2Zn
- IUPAC Name:
- zinc(II) 9-octadecenoate
- Reference substance name:
- Zinc dilinoleate
- EC Number:
- 235-870-2
- EC Name:
- Zinc dilinoleate
- Cas Number:
- 13014-44-3
- Molecular formula:
- C36H62O4Zn
- IUPAC Name:
- zinc(II) 9,12-octadecdienoate
- Test material form:
- solid: bulk
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
Constituent 6
Constituent 7
Constituent 8
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Species and strain : NSam: Sprague-Dawley Rat
Microbiological grade : Specific Pathogen Free(SPF)
Sex : Female(nulliparous and non-pregnant)
Breeder : Samtako Bio Korea
(105, Seorang-ro, Osan-si, Gyeonggi-do, Republic of Korea)
Supplier : Young Bio Co., Ltd.
(388, Dunchon-daero, Jungwon-gu, Seongnam-si, Gyeonggi-do,
Republic of Korea)
Step Age(week old) Sex Number of animals
Animals at acquisition 8 Female 13
1st step administration 9 Female 3
2nd step administration 9 Female 3
3rd step administration 10 Female 3
4th step administration 10 Female 3
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- The test substance was administered in single dosing at a dose level of 300 mg/kg b.w.(1st and 2nd step) and 2,000 mg/kg b.w.(3rd and 4th step).
- No. of animals per sex per dose:
- 3
- Control animals:
- not specified
- Details on study design:
- 3.1.2. Dose level
1st step The starting dose level was selected as 300 mg/kg body weight (b.w.) due to a lack of
toxicity information of the test substance.
2nd step After the 1st step dosing(before the 2nd step dosing), no dead animals were observed.
Thus, the 2nd step dose level was selected as 300 mg/kg b.w..
3rd step After the 2nd step dosing(before the 3rd step dosing), no dead animals were observed.
Thus, the 3rd step dose level was selected as 2,000 mg/kg b.w..
4th step After the 3rd step dosing(before the 4th step dosing), no dead animals were observed.
Thus, the 4th step dose level was selected as 2,000 mg/kg b.w..
3.2. Administration of Test Substance
3.2.1. Justification for route of administration
The oral route was selected to investigate the oral toxicity of test substance.
3.2.2. Dose frequency
Single administration
3.2.3. Dosage
The dose volume was set as 5 mL/kg b.w., and the dosage for each animal were calculated on the
basis of fasted body weight on the administration day.
3.2.4. Method
The animals were fasted for over-night(over 16 hours with water provided ad libitum) and orally
administered once by gavage using a feeding needle(gavage needle). Feed was provided
approximately 4 hours post-dosing.
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed in this study.
- Clinical signs:
- other:
- Body weight:
- other body weight observations
- Remarks:
- No body weight changes related to the test substance administration were observed in all animals in the 300 mg/kg b.w.(1st and 2nd step) and 2,000 mg/kg b.w.(3rd and 4th step) groups.
- Gross pathology:
- No gross lesions related to the test substance administration were observed in all animals in the 300 mg/kg b.w.(1st and 2nd step) and 2,000 mg/kg b.w.(3rd and 4th step) groups.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- This study was conducted to confirm the GHS category and LD50 cut-off value based on the acute toxicity of the test substance, Fatty acids, C8-18 and C18-unsatd., zinc salts, following a single oral administration to female Sprague-Dawley rats. The test substance was administered in a single dose at dose of 300 mg/kg b.w.(1st and 2nd step) and 2,000 mg/kg b.w.(3rd and 4th step). Three animals were used for each step. Mortality, clinical signs and body weights were observed for 14 days. Also, at the end of the 14-day observation period for each step, gross necropsy was performed.
No mortality was observed in this study.
No clinical signs were observed in the 300 mg/kg b.w.(1st and 2nd step) and 2,000 mg/kg b.w.(3rd and 4th step) groups.
No body weight changes related to the test substance administration were observed in all animals in the 300 mg/kg b.w.(1st and 2nd step) and 2,000 mg/kg b.w.(3rd and 4th step) groups.
No gross lesions related to the test substance administration were observed in all animals in the 300 mg/kg b.w.(1st and 2nd step) and 2,000 mg/kg b.w.(3rd and 4th step) groups.
As a result, the test substance, Fatty acids, C8-18 and C18-unsatd., zinc salts, was confirmed as GHS (Globally Harmonized System of Classification and Labelling of Chemicals) Category 5 and the oral LD50 cut-off was determined as greater than 2,000 mg/kg b.w. in this study.
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