Registration Dossier
Registration Dossier
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EC number: 225-767-0 | CAS number: 5063-03-6
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Documentation about the justification is provided in attachment (See Supporting information). The reliability assessment of the prediction is presented in the attached document as well (QPRF). QSAR model reporting format is presented in the file QMRF attached.
Data source
Reference
- Reference Type:
- other: QSAR model
- Title:
- VEGA in silico platform
- Year:
- 2 022
- Bibliographic source:
- Algae Acute (EC50) Toxicity model (ProtoQSAR/Combase) 1.0.1
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.
Test material
- Reference substance name:
- Methyl (8,9,10-trinorborn-5-en-2-yl) ketone
- EC Number:
- 225-767-0
- EC Name:
- Methyl (8,9,10-trinorborn-5-en-2-yl) ketone
- Cas Number:
- 5063-03-6
- Molecular formula:
- C9H12O
- IUPAC Name:
- 1-{bicyclo[2.2.1]hept-5-en-2-yl}ethan-1-one
Constituent 1
- Specific details on test material used for the study:
- O=C(C)C2CC1C=CC2(C1)
Results and discussion
Effect concentrations
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 70.97 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Remarks on result:
- other:
- Remarks:
- Predicted by ProtoQSAR/Combase v.1.0.0
Any other information on results incl. tables
The prediction was deemed to be reliable on the basis of the parameters listed above. The molecule falls into the applicability domain of the model.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The substance was predicted to have a EC50 of 70.97 mg/L for Algae.
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