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EC number: 244-848-1 | CAS number: 22224-92-6
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015-11-09
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- capillary method
- Key result
- Melting / freezing pt.:
- >= 46 - <= 50 °C
- Decomposition:
- no
- Sublimation:
- no
- Conclusions:
- The melting temperature of the test item was determined to be in the range from 46.0 to 50.0 °C.
- Executive summary:
An experimental study was conducted similar to Regulation (EC) No 440/2008 Method A.1. and OECD Test Guidelines 102 to determine the melting range of the test item using the capillary method. The capillary tube was placed in the apparatus and heated at 1 °C/minute until melting was complete. Two test runs were performed. The melting temperature of the test item was determined to be in the range from 46.0 to 50.0 °C.
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- from 1999-09-17 to 2000-03-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- hot stages
- Key result
- Melting / freezing pt.:
- >= 43 - <= 49 °C
- Decomposition:
- no
- Sublimation:
- no
- Conclusions:
- The melting range of the test item was determined to be 43 – 49 °C.
- Executive summary:
An experimental study was conducted similar to Regulation (EC) No 440/2008 Method A.1. and OECD Test Guidelines 102 to determine the melting range of the test item. The melting range of the reference substance was determined using a melt microscope. A small quantity of the test item was heated with around 1 °C/min. The melting was observed through the microscope. Three test runs were performed. The melting range of the test item was determined to be 43 – 49 °C.
Referenceopen allclose all
Melting stage as referenced in OECD 102 | Temperature Sample I | Temperature Sample II |
A | 46.0 | 46.0 |
B | 47.5 | 47.5 |
C | 49.5 | 49.0 |
D | 50.0 | 50.0 |
E | 50.5 | 50.0 |
Test | Original crystals melting at [°C] | After recrystallization by means of refigeration and rubbing on the slide melting at [°C] |
No. 1 | Main part: 43.3 – 47.8 Several crystals: 48.8 | 43.1 – 47.5 |
No. 2 | 43.5 – 47.8 | Several crystals: 44.5 Rest crystals: 46.9 – 47.8 |
No. 3 | Several small crystals: 42.9 Main part: 44.6 – 47.3 Rest crystals: 48.9 | Small crystals: 43.1 – 46.3 Rest Crystals: 46.6 – 47.9 |
Melting range | 43 – 49 °C |
|
Description of key information
The melting temperature of the test item was determined to be in the range from 46.0 to 50.0 °C.
Key value for chemical safety assessment
Additional information
Key Study:
An experimental study was conducted similar to Regulation (EC) No 440/2008 Method A.1. and OECD Test Guidelines 102 to determine the melting range of the test item using the capillary method. The capillary tube was placed in the apparatus and heated at 1 °C/minute until melting was complete. Two test runs were performed. The melting temperature of the test item was determined to be in the range from 46.0 to 50.0 °C.
Supporting Study:
An experimental study was conducted similar to Regulation (EC) No 440/2008 Method A.1. and OECD Test Guidelines 102 to determine the melting range of the test item. The melting range of the reference substance was determined using a melt microscope. A small quantity of the test item was heated with around 1 °C/min. The melting was observed through the microscope. Three test runs were performed. The melting range of the test item was determined to be 43 – 49 °C.
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