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EC number: 428-790-6 | CAS number: 72963-72-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 16 - February 17, 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2600 (Skin Sensitisation)
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- Buehler test
- Justification for non-LLNA method:
- A dermal sesitisation test in Guinea pig was already available.
Test material
- Reference substance name:
- -
- EC Number:
- 428-790-6
- EC Name:
- -
- Cas Number:
- 72963-72-5
- Molecular formula:
- C17H22N2O4
- IUPAC Name:
- [2,5-dioxo-3-(prop-2-yn-1-yl)imidazolidin-1-yl]methyl (1R,3R)-2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane-1-carboxylate; [2,5-dioxo-3-(prop-2-yn-1-yl)imidazolidin-1-yl]methyl (1R,3S)-2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane-1-carboxylate
- Test material form:
- liquid: viscous
- Details on test material:
- Name: Imiprothrin
Appearance: viscous liquid
Colour: amber
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male/female
- Details on test animals and environmental conditions:
- Number of Animals: 34
Number of Groups: 3
Sex: Male and Female. All females assigned to test were nulliparous and non-pregnant.
Species/Strain: Guinea pigs/Hartley albino.
Age/Body Weight: Preliminary Irritation Group: Young adult (male or female)
Test and Naive Control Groups: Young adult males/457-567 grams at experimental start.
Housing: The animals were group housed in plastic solid bottom polycarbonate caging,
Animal Room Temperature and Relative Humidity Ranges: 19-23ºC and 43-58%, respectively.
Animal Room Air Changes/Hour: 12.
Photoperiod: 12-hour light/dark cycle
Acclimation Period: 21-48 days
Food/water: ad libitum
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, occlusive
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- four-tenths of a milliliter
- Day(s)/duration:
- 6 hours
Challenge
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Concentration / amount:
- four-tenths of a milliliter
- Day(s)/duration:
- 2
- No. of animals per dose:
- Preliminary Irritation Group: 4
Test Group: 20
Naive Control Group: 10 - Details on study design:
- Induction Phase
Once each week for three weeks, four-tenths of a milliliter of the neat test substance was applied to the left side of each test animal using an occlusive 25 mm Hill Top Chamber. The chambers were secured in place and wrapped with non-allergenic Durapore adhesive tape to avoid dislocation of the chambers and to minimize loss of the test substance for six hours. After the 6-hour exposure period, the chambers were removed and the test sites were gently cleansed with a 3% soap solution followed by tap water and a clean paper towel to remove any residual test substance. Approximately 24 and 48 hours after each induction application, readings were made of local reactions (erythema) .
Challenge Phase
Twenty-seven days after the first induction dose, four-tenths of a milliliter of the neat test substance (100%, HNIC) was applied to a naive site on the right side of each animal as a challenge dose, using the procedures described above. These sites were evaluated for a sensitization response (erythema) approximately 24 and 48 hours after the challenge application.
In addition to the test animals, 10 guinea pigs from the same shipment were maintained under identical environmental conditions and were treated with the HNIC of the test substance at challenge only. These animals constituted the "naive control" group. - Positive control substance(s):
- yes
- Remarks:
- alpha-Hexylcinnamaldehyde (HCA)
Results and discussion
- Positive control results:
- Induction Phase:
Historical Positive Control Animals (100% HCA): Very faint erythema (0.5) was noted at most positive control sites during the induction phase. Faint erythema (1) was noted at five sites 24 and/or 48 hours after the second and/or third induction application.
Challenge Phase:
Historical Positive Control Animals (100% HCA): Six of ten positive control animals exhibited signs of a sensitization response (faint erythema [1]) 24 hours after the challenge application. Positive responses persisted at five of the positive control sites from 24 hours through 48 hours. Very faint erythema (0.5) was noted at three other sites at 24 and/or 48 hours after the challenge application.
Historical Naive Control Animals (100% HCA): Very faint erythema (0.5) was noted at four naive control sites at 24 and 48 hours after the challenge application.
In vivo (non-LLNA)
Resultsopen allclose all
- Key result
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 100% test substance
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 100% test substance
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- positive control
- Dose level:
- 100 % HCA
- No. with + reactions:
- 6
- Total no. in group:
- 10
- Clinical observations:
- faint erythema
- Remarks on result:
- other: Historical control data
- Key result
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- positive control
- Dose level:
- 100 % HCA
- No. with + reactions:
- 5
- Total no. in group:
- 10
- Clinical observations:
- faint erythema
- Remarks on result:
- other:
- Remarks:
- Historical control data
- Group:
- negative control
- Remarks on result:
- not measured/tested
Any other information on results incl. tables
There was no dermal irritation observed at any test site during the induction phase.
There was no dermal irritation observed at any test site during the challenge phase.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the results of this study, the test substance is not considered to be a contact sensitizer.
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