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EC number: 423-640-6 | CAS number: 179911-08-1 AGARBOIS
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21 July 1996 to 26 July 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- N-ethyl-N-(3-methylphenyl)propionamide
- EC Number:
- 423-640-6
- EC Name:
- N-ethyl-N-(3-methylphenyl)propionamide
- Cas Number:
- 179911-08-1
- Molecular formula:
- C12H17NO
- IUPAC Name:
- N-ethyl-N-(3-methylphenyl)propanamide
- Test material form:
- liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Samples for analysis were taken at 0, 24, 48, 72 and 96 hours old and new for all concentrations.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- At -24 hours (21/07/96) 1.51 g of test item (S032) was weighed out and added to 15 litres of carbon filtered tap water (CFTW). This solution was stirred overnight to give a 100 mg/I stock (nominal concentration). This stock was prepared daily and test media prepared by appropriate dilution of the stock as 0, 10, 18, 32, 56 and 100 mg/l
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebra fish
- Strain: Brachydanio rerio
- Length at study initiation (length definition, mean, range and SD): 0.21g
- Weight at study initiation (mean and range, SD): 3.1 cm
- Method of breeding: fed on live and proprietary fish food (Artemis and Tetramin)
- The test fish were isolated 72 hours prior to the start of the test
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 111 as mg/l CaCo3
- Test temperature:
- 26.1°C
- pH:
- 7.9
- Dissolved oxygen:
- 7.1
- Nominal and measured concentrations:
- Nominal: 0, 10, 18, 32, 56 and 100 mg/l
Measured concentrations (geometric mean): 0.0, 5.37, 11.69, 22.39, 43.40 and 100.97 mg/l - Details on test conditions:
- TEST SYSTEM
- Test vessel: 6 litre capacity all glace tank
- Type (delete if not applicable): open
- Material, size, headspace, fill volume: 6 litres
- Aeration: Yes
- Renewal rate of test solution (frequency/flow rate): renewal of test medium every 24 hours
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): No replicates
- No. of vessels per control (replicates): none
- No. of vessels per vehicle control (replicates): 1
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : abnormalities in swimming, loss of balance and mortality
- Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 66 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The effect concentrations calculated by the binomial method were:
LC50 95% conservative confidence interval (mg/l)
mg/l
24 hours 65 42 - 101
96 hours 66 43 - 101
The lowest concentration causing 100 % mortality at 96 hours was 101 mg/I.
The highest concentration causing 0 % mortality at 96 hours was 43 mg/I.
The 96 hour NOEC (swimming activity) is between 0.0 and 5.4 mg/I. - Executive summary:
The acute toxicity of the test item to the fresh-water fish Brachydanio rerio (zebra fish) was determined according to a standard method conforming to OECD Guideline 203 and EEC Directive 92/69/EEC L383.
The test was conducted under static renewal conditions with renewal of test media every 24 hours.
Effect concentrations are based on the geometric mean of measured values. The effect concentrations calculated by the binomial method were:
L
h
t
LC50
95%conservative confidence interval (mg/I)
(mg/I)
24 hours
65
42 - 101
96 hours
66
43 - 101
The lowest concentration causing 100% mortality at 96 hours was 101 mg/l.
The highest concentration causing 0 %mortality at 96 hours was 43 mg/l.
The 96 hour NOEC (swimming activity) is between 0.0 and 5.4 mg/l.
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