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EC number: 406-140-2 | CAS number: 114369-43-6 INDAR
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EPA Guideline number: 835.1230
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- batch equilibrium method
- Media:
- soil
Test material
- Reference substance name:
- 4-(4-chlorophenyl)-2-phenyl-2-[(1H-1,2,4-triazol-1-yl)methyl]butanenitrile
- EC Number:
- 406-140-2
- EC Name:
- 4-(4-chlorophenyl)-2-phenyl-2-[(1H-1,2,4-triazol-1-yl)methyl]butanenitrile
- Cas Number:
- 114369-43-6
- Molecular formula:
- C19H17ClN4
- IUPAC Name:
- 4-(4-chlorophenyl)-2-phenyl-2-[(1H-1,2,4-triazol-1-yl)methyl]butanenitrile
1
Study design
- Test temperature:
- 25°C
Batch equilibrium or other method
- Analytical monitoring:
- yes
- Details on sampling:
- Concentration of test solutions:
High: 0.334 ppm
Medium High: 0.224 ppm
Medium: 0.107 ppm
Low: 0.039 ppm
Radioassay was used to determine the concentration of each solution. Combustion radioassay was used to determine the concentration remaining in the soil.
Matrix propertiesopen allclose all
- Matrix no.:
- #1
- Matrix type:
- clay
- % Clay:
- 56
- % Silt:
- 20.8
- % Sand:
- 23.2
- % Org. carbon:
- 0.4
- pH:
- 5.3
- CEC:
- 4.5 meq/100 g soil d.w.
- Matrix no.:
- #2
- Matrix type:
- loam
- % Clay:
- 22
- % Silt:
- 48.8
- % Sand:
- 29.2
- % Org. carbon:
- 2.4
- pH:
- 7.2
- CEC:
- 15.7 meq/100 g soil d.w.
- Matrix no.:
- #3
- Matrix type:
- sand
- % Clay:
- 6
- % Silt:
- 0.8
- % Sand:
- 93.2
- % Org. carbon:
- 0.5
- pH:
- 7.3
- CEC:
- 2.1 meq/100 g soil d.w.
- Matrix no.:
- #4
- Matrix type:
- sandy loam
- % Clay:
- 13.2
- % Silt:
- 18
- % Sand:
- 68.8
- % Org. carbon:
- 2.2
- pH:
- 5.4
- CEC:
- 8.7 meq/100 g soil d.w.
- Matrix no.:
- #5
- Matrix type:
- silty clay loam
- % Clay:
- 29.2
- % Silt:
- 62
- % Sand:
- 8.8
- % Org. carbon:
- 1.2
- pH:
- 7
- CEC:
- 6.6 meq/100 g soil d.w.
- Details on matrix:
- Cecil Clay, Keeton Loam, Lakeland Sand, Pasquotank Sandy Loam, Lawrenceville Silty Clay Loam
- Details on test conditions:
- The adsorption properties of 14C test substance were studied on five soils by mixing the soil and an aqueous 0.01 N CaC12 solution of test substance, at ambient temperature and four concentration levels (nominally 0.3, 0.2, 0.1 and 0.03 ppm). After allowing 24 hours for equilibration, the concentration of test substance in solution was measured. The soils tested were clay, loam, sand, sandy loam and silty clay loam. The ratios of soil to solution were approximately 1:5 for the clay and sand, 1:20 for the loam and sandy loam and 1:12 for the silty clay loam. Desorption was determined by rinsing each of the soils used for the adsorption with fresh 0.01 N CaC12, and after 72 hours, measuring the distribution of test substance in both media. Radioassay was used to determine the concentration of each solution. Combustion radioassay was used to determine the concentration remaining in the soil.
Duration of adsorption equilibrationopen allclose all
- Sample No.:
- #1
- Duration:
- 24 h
- Sample No.:
- #2
- Duration:
- 24 h
- Sample No.:
- #3
- Duration:
- 24 h
- Sample No.:
- #4
- Duration:
- 24 h
- Sample No.:
- #5
- Duration:
- 24 h
Duration of desorption equilibrationopen allclose all
- Sample no.:
- #1
- Duration:
- 72 h
- Sample no.:
- #2
- Duration:
- 72 h
- Sample no.:
- #3
- Duration:
- 72 h
- Sample no.:
- #4
- Duration:
- 72 h
- Sample no.:
- #5
- Duration:
- 72 h
Results and discussion
Adsorption coefficientopen allclose all
- Key result
- Sample No.:
- #1
- Type:
- Kd
- Value:
- 5.07
- Matrix:
- Cecil Clay
- % Org. carbon:
- 0.23
- Key result
- Sample No.:
- #2
- Type:
- Kd
- Value:
- 75.206
- Matrix:
- Keeton Loam
- % Org. carbon:
- 1.39
- Key result
- Sample No.:
- #3
- Type:
- Kd
- Value:
- 7.563
- Matrix:
- Lakeland Sand
- % Org. carbon:
- 0.29
- Key result
- Sample No.:
- #4
- Type:
- Kd
- Value:
- 115.396
- Matrix:
- Pasquotank Sandy Loam
- % Org. carbon:
- 1.28
- Key result
- Sample No.:
- #5
- Type:
- Kd
- Value:
- 20.079
- Matrix:
- Lawrenceville Silty Clay Loam
- % Org. carbon:
- 0.7
- Key result
- Sample No.:
- #1
- Type:
- Koc
- Value:
- 2 185.3
- Matrix:
- Cecil Clay
- % Org. carbon:
- 0.23
- Key result
- Sample No.:
- #2
- Type:
- Koc
- Value:
- 5 402.3
- Matrix:
- Keeton Loam
- % Org. carbon:
- 1.39
- Key result
- Sample No.:
- #3
- Type:
- Koc
- Value:
- 2 607.8
- Matrix:
- Lakeland Sand
- % Org. carbon:
- 0.29
- Key result
- Sample No.:
- #4
- Type:
- Koc
- Value:
- 9 042.8
- Matrix:
- Pasquotank Sandy Loam
- % Org. carbon:
- 1.28
- Key result
- Sample No.:
- #5
- Type:
- Koc
- Value:
- 2 884.6
- Matrix:
- Lawrenceville Silty Clay Loam
- % Org. carbon:
- 0.7
Results: Batch equilibrium or other method
- Adsorption and desorption constants:
- Kd (ads,des):
Clay: (5.07, 7.10)
Loam: (75.21, 147.6)
Sand: (7.56, 2.33)
Sandy Loam: (115.4, 132.2)
Silty Clay Loam: (20.08, 33.00)
For the loam and sandy loam, the adsorption of test substance appears to be irreversible.
Koc:
The adsorption constant, Koc, for 14C test substance was calculated as an average of the values found for each soil and found to be 4425.
Cecil Clay: 2185.3
Keeton Loam: 5402.3
Lakeland Sand: 2607.8
Pasquotank Sandy Loam: 9042.8
Lawrenceville Silty Clay Loam: 2884.6 - Recovery of test material:
- To ensure that radioactivity was not lost due to adhesion of test substance to the sides of the centrifuge tubes used in the course of this study. 10 mL of each test solution were placed in an empty Teflon tube and shaken for 24 hours. Duplicate 0.5 mL samples of each solution were
radioassayed. There was no significant'loss of radioactivity in any of the test solutions.
Mass balance (%) at end of adsorption phaseopen allclose all
- Sample no.:
- #1
- % Adsorption:
- 59.52
- Remarks on result:
- other: Fortification: 3.34 µg
- Sample no.:
- #1
- % Adsorption:
- 60.36
- Remarks on result:
- other: Fortification: 2.24 µg
- Sample no.:
- #1
- % Adsorption:
- 64.17
- Remarks on result:
- other: Fortification: 1.07 µg
- Sample no.:
- #1
- % Adsorption:
- 64.46
- Remarks on result:
- other: Fortification: 0.39 µg
- Sample no.:
- #2
- % Adsorption:
- 79.59
- Remarks on result:
- other: Fortification: 12.69 µg
- Sample no.:
- #2
- % Adsorption:
- 80.7
- Remarks on result:
- other: Fortification: 8.51 µg
- Sample no.:
- #2
- % Adsorption:
- 80.9
- Remarks on result:
- other: Fortification: 3.96 µg
- Sample no.:
- #2
- % Adsorption:
- 80.15
- Remarks on result:
- other: Fortification: 1.44 µg
- Sample no.:
- #3
- % Adsorption:
- 52.97
- Remarks on result:
- other: Fortification: 3.34 µg
- Sample no.:
- #3
- % Adsorption:
- 54.41
- Remarks on result:
- other: Fortification: 2.24 µg
- Sample no.:
- #3
- % Adsorption:
- 42.49
- Remarks on result:
- other: Fortification: 1.07 µg
- Sample no.:
- #3
- % Adsorption:
- 44
- Remarks on result:
- other: Fortification: 0.39 µg
- Sample no.:
- #4
- % Adsorption:
- 85.13
- Remarks on result:
- other: Fortification: 12.69 µg
- Sample no.:
- #4
- % Adsorption:
- 86.52
- Remarks on result:
- other: Fortification: 8.51 µg
- Sample no.:
- #4
- % Adsorption:
- 88.1
- Remarks on result:
- other: Fortification: 3.96 µg
- Sample no.:
- #4
- % Adsorption:
- 85.03
- Remarks on result:
- other: Fortification: 1.44 µg
- Sample no.:
- #5
- % Adsorption:
- 71.14
- Remarks on result:
- other: Fortification: 8.35 µg
- Sample no.:
- #5
- % Adsorption:
- 72
- Remarks on result:
- other: Fortification: 5.6 µg
- Sample no.:
- #5
- % Adsorption:
- 75.72
- Remarks on result:
- other: Fortification: 2.68 µg
- Sample no.:
- #5
- % Adsorption:
- 78.26
- Remarks on result:
- other: Fortification: 0.98 µg
- Transformation products:
- no
- Details on results (Batch equilibrium method):
- Both TLC and HPLC indicate that the test substance triazole was stable to test conditions. No other radioactive residues were detectable in either the autoradiogram or the HPLC chromatogram.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The findings of this study demonstrate that the test substance has only slight potential for mobility in soil and should not contaminate ground water though leaching. The mean Koc value was 4425.
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