Registration Dossier
Registration Dossier
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EC number: 203-883-2 | CAS number: 111-57-9
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From June 19, 2012 to August 27, 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- For surface active substances the critical micelle concentration (CMC) method is used as an alternative to the water solubility. The critical micelle concentration (CMC) is determined by measuring the surface tension of test substance solutions at different test substance concentration. For surface active substances which form micelles in solution, the surface tension decreases with increasing concentration until the CMC is reached. At concentrations above the CMC, the surface tension remains constant. The CMC is determined from a plot of the surface tension versus the logarithm of the test substance concentration.
- GLP compliance:
- yes
- Type of method:
- other: critical micelle concentration (CMC)
- Water solubility:
- 1 mg/L
- Temp.:
- 20 °C
- Remarks on result:
- other: No information on pH available
- Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L) < 1 mg/L
Under the conditions of the study, the water solubility of the test substance was determined to be <1 mg/L at 20°C. - Executive summary:
A study was conducted to determine the water solubility of the test substance using CMC method according to GLP. Under the conditions of the study, the water solubility of the test substance was determined to be <1 mg/L at 20 °C.
Reference
Description of key information
The water solubility was determined from the critical micellar concentration (Baltussen, 2012).
Further water solubility testing according to OECD Guideline 105 is planned.
Key value for chemical safety assessment
- Water solubility:
- 1 mg/L
- at the temperature of:
- 20 °C
Additional information
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