Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Automatic calculation with MeClas tool
Data source
Reference
- Reference Type:
- other: software
- Title:
- Unnamed
- Year:
- 2 014
Materials and methods
- Principles of method if other than guideline:
- Eye irritation potential of pNMC oxide (generic composition) was determined by classifying based on the Mixture rules from EU CLP (additivity formula of classified components to derive hazard class) and back calculation to the corresponding acute toxicity range estimate.
Test material
- Reference substance name:
- Nickel Cobalt Manganese Hydroxide
- EC Number:
- 839-353-8
- Cas Number:
- 189139-63-7
- Molecular formula:
- Molecular formula: Ni1-x-yMnxCoy(OH)2, Stoechiometry of (Me = Ni + Co + Mn) equals 1, ranges of the elements approx. as: Ni/Me = 0.25 – 0.95 Mn/Me = 0.02 – 0.40 Co/Me = 0.02 – 0.40 OH = 2.00
- IUPAC Name:
- Nickel Cobalt Manganese Hydroxide
- Reference substance name:
- Manganese dihydroxide
- Cas Number:
- 18933-05-6
- Molecular formula:
- Mn(OH)2
- IUPAC Name:
- Manganese dihydroxide
- Reference substance name:
- Cobalt dihydroxide
- EC Number:
- 244-166-4
- EC Name:
- Cobalt dihydroxide
- Cas Number:
- 21041-93-0
- Molecular formula:
- CoH2O2
- IUPAC Name:
- cobalt(2+) dihydroxide
- Reference substance name:
- Nickel dihydroxide
- EC Number:
- 235-008-5
- EC Name:
- Nickel dihydroxide
- Cas Number:
- 12054-48-7
- Molecular formula:
- H2NiO2
- IUPAC Name:
- nickel(2+) dihydroxide
- Test material form:
- solid: particulate/powder
1
Constituent 1
Constituent 2
Constituent 3
Results and discussion
In vitro
Results
- Irritation parameter:
- other: Calculation by MeClas
- Remarks on result:
- other: mixture rules, based on the hazartd properties of the constituents
- Other effects / acceptance of results:
- It was calculated that the substance pNMC oxide was not irritant to the eye.
Applicant's summary and conclusion
- Conclusions:
- An Eye Irrit. Cat.2 classification was determined theoretically with MeClas
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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