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EC number: 457-830-5 | CAS number: 2557-13-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EEC Directive 96/54 B.7 (OECD 407)
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 457-830-5
- EC Name:
- -
- Cas Number:
- 2557-13-3
- Molecular formula:
- Hill formula: C9 H7 F3 O2
- IUPAC Name:
- Methyl, 3-Trifluoromethylbenzoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- olive oil
- Details on oral exposure:
- Method of administration:
gavage - Duration of treatment / exposure:
- Test duration: 28 days
- Frequency of treatment:
- Dosing regime: 7 days/week
- No. of animals per sex per dose:
- Male: 5 animals at 100 mg/kg bw/day
Male: 5 animals at 300 mg/kg bw/day
Male: 5 animals at 1000 mg/kg bw/day
Female: 5 animals at 100 mg/kg bw/day
Female: 5 animals at 300 mg/kg bw/day
Female: 5 animals at 1000 mg/kg bw/day
Results and discussion
Results of examinations
- Details on results:
- Clinical observations:
No animal died during the study period.
1000 mg/kg body weight/day:
. Anogenital region smeared with urine, seen in 4 males and
5 females
. Piloerection obtained in 4 males and 4 females on several
days of the study, predominantly 3 to 4 hours after
substance administration
. Salivation slight to severe, observed in all males and
females beyond the first week ofmadministration until the
end of the study (before as well as up to 4 hours after treatment)
. Water consumption increased, statistically significant in
males on days 7, 14 and 28 and in females on days 7, 14 and 21
. Unsteady gait obtained in all males and females on day 22
and additionally in one animal of each sex on day 23
. Slight tremors in 2 males and stiff gait in 1 female
animal observed during functional observational battery,
additionally to the above-mentioned clinical findings
. Overall motor activity significantly reduced in males and
females (in addition several single intervals were reduced
in females)
. Increased alanine aminotransferase, alkaline phosphatase,
magnesium, urinary volume, abnormal urinary crystals and
renal tubular epithelial cells in both sexes
. Increased total bilirubin and triglycerides in females and
increased granular casts in males
. Decreased total protein and globulins in both sexes and
decreased albumin in males
. Increased absolute and relative liver weights in male and
female animals
300 mg/kg body weight/day:
. Salivation slight to moderate, observed in all males
beyond the first week of administration until the end of the
study (before as well as up to 4 hours after treatment)
. Slight salivation in 1 female animal observed during
functional observational battery
. Water consumption increased, statistically significant in
males on day 14
100 mg/kg body weight/day:
. No substance-related adverse findings
Laboratory findings:
There are no treatment-related changes in the hematological
parameters measured.
Effects in organs:
All findings noted were single observations either, or were
similarly in distribution pattern and severity in control
rats compared to treatment groups. All of them are
considered to be incidental and/or spontaneous in origin.
All findings noted were single observations either, or were
similarly in distribution pattern and severity in control
rats compared to treatment groups. All of them are
considered to be incidental and/or spontaneous in origin.
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 100 mg/kg bw/day (nominal)
- Basis for effect level:
- other: original NCD unit is mg/kg/day.
- Dose descriptor:
- NOEL
- Effect level:
- 100 mg/kg bw/day (nominal)
- Basis for effect level:
- other: original NCD unit is mg/kg/day.
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Signs of general systemic toxicity as well as neurological effects could be determined at 1000 mg/kg body weight per day over a period of 4 weeks. Only minor effects were obtained in mid dose animals. Target Organs were liver and kidneys.
Under the conditions of the present study, the no observed adverse effect level (NOAEL) was 100 mg/kg body weight per day in both sexes.
Applicant's summary and conclusion
- Conclusions:
- signs of general systemic toxicity as well as neurological effects could be
determined at 1000 mg/kg body weight per day over a period of 4 weeks. Only minor
effects were obtained in mid dose animals. Target Organs were liver and kidneys.
Under the conditions of the present study, the no observed adverse effect level (NOAEL)
was 100 mg/kg body weight per day in both sexes.
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