Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 271-587-0 | CAS number: 68585-78-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP-compliant, guideline study with some deviations
- Justification for type of information:
- Read across valid as the substnace tested is also titanate complex with alkylphosphate, degrading in water to form simple alcohols including 2-propanol and phosphate esters.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- yes
- Principles of method if other than guideline:
- No analytical monitoring was described in the study report and so it could not be confirmed that concentrations were maintained within 80% of nominal.
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- Source: HRC Ltd sewage treatment plant (aeration stage). Collection: 30 May 1986. Preparation: sample was settled and Whatman GFA filter paper was used to filter the supernant after the first 250 ml was discarded. Dilution water: standard nutrient medium.
- Duration of test (contact time):
- 28 d
- Details on study design:
- Temperature: 20 +/- 1°C, incubated in water bath. Vessels: 300 ml darkened glass bottle with glass stoppers. Concentrations: (1) 2 mg/L titanium butyl phosphate; (2) 3 mg/L sodium benzoate; (3) inoculated dilution water; (4) non-inolculated dilution water. 1 drop of activated sludge filtrate per litre was used to inoculate media. Bottles were filled and stoppered in a manner to exclude all air bubbles.
- Reference substance:
- benzoic acid, sodium salt
- Preliminary study:
- No data reported
- Test performance:
- Oxygen depletion at test termination: 2.875 mgO2/L. Chemical Oxygen Demand: 3.00 mgO2/L.
- Parameter:
- % degradation (O2 consumption)
- Value:
- 96
- Sampling time:
- 28 d
- Details on results:
- Inoculated and non-inoculated controls all had oxygen depletion in the prescribed limits.
- Results with reference substance:
- Sodium benzoate reached 97% degradation in 28 days.
- Validity criteria fulfilled:
- not applicable
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The target substance is readily biodegradable based on studies read across from structural analogue.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 May to 27 June 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP-compliant, guideline study with some deviations
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- yes
- Remarks:
- No analytical monitoring was described in the study report and so it could not be confirmed that concentrations were maintained within 80% of nominal.
- Principles of method if other than guideline:
- No analytical monitoring was described in the study report and so it could not be confirmed that concentrations were maintained within 80% of nominal.
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- Source: HRC Ltd sewage treatment plant (aeration stage). Collection: 30 May 1986. Preparation: sample was settled and Whatman GFA filter paper was used to filter the supernant after the first 250 ml was discarded. Dilution water: standard nutrient medium.
- Duration of test (contact time):
- 28 d
- Details on study design:
- Temperature: 20 +/- 1°C, incubated in water bath. Vessels: 300 ml darkened glass bottle with glass stoppers. Concentrations: (1) 2 mg/L titanium butyl phosphate; (2) 3 mg/L sodium benzoate; (3) inoculated dilution water; (4) non-inolculated dilution water. 1 drop of activated sludge filtrate per litre was used to inoculate media. Bottles were filled and stoppered in a manner to exclude all air bubbles.
- Reference substance:
- benzoic acid, sodium salt
- Preliminary study:
- No data reported
- Test performance:
- Oxygen depletion at test termination: 2.875 mgO2/L. Chemical Oxygen Demand: 3.00 mgO2/L.
- Parameter:
- % degradation (O2 consumption)
- Value:
- 96
- Sampling time:
- 28 d
- Details on results:
- Inoculated and non-inoculated controls all had oxygen depletion in the prescribed limits.
- Results with reference substance:
- Sodium benzoate reached 97% degradation in 28 days.
- Validity criteria fulfilled:
- no
- Remarks:
- No analytical monitoring and so concentrations could not be verified to have been maintained with 80% of nominal.
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The oxygen depletion indicated that IA10 biodegraded 96% in 28 days, indicating that it is readily biodegradable.
- Executive summary:
Doulgas (1986) is a GLP-compliant, closed bottle ready biodegradability test following OECD guideline 301D. No analytical monitoring was described in the study report and so it was not verified that concentrations were maintained within 80% of nominal. However the vessels were kept tightly shut and other studies have shown that the test substance hydrolyses rapidly on contact with water, this is not considered to have had an adverse effect on the outcome of the results. The study is considered reliable and suitable for use for this endpoint.
Referenceopen allclose all
Description of key information
No study was conducted on the target substance. Read-across from structural analogue, Titanium butyl phosphate, is valid in that both substances are hydrolytically unstable and forms simple alcohols, including 2-propanol, and phosphate esters.
Based on the results of the structural analogue, the target substance is readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.