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Diss Factsheets
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EC number: 222-158-1 | CAS number: 3373-59-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_physical-and-chemical-properties.png)
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013-03-19 to 2013-11-06
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: L-TME was assessed using particle size apparatus based on laser diffraction
- Deviations:
- not applicable
- Principles of method if other than guideline:
- The size distribution of particles was assessed using particle size apparatus based on laser diffraction
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- Laser scattering/diffraction
- Type of distribution:
- mass based distribution
Test material
- Reference substance name:
- Methyl L-threoninate
- EC Number:
- 222-158-1
- EC Name:
- Methyl L-threoninate
- Cas Number:
- 3373-59-9
- Molecular formula:
- C5H11NO3
- IUPAC Name:
- Methyl (2S,3R)-2-amino-3-hydroxy-butanoate
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study report): L-threonine methyl ester
- Physical state: white crystalline powder
- Analytical purity: 99.8%
Constituent 1
- Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch number of test material: X5UYC99
- Expiration date of the lot/batch: July2014
- Purity test date: 99.8 %
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Frozen (ca. -20 ̊C)
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Preparation of a nanomaterial dispersion (incl. dilution):
A saturated solution of L-threonine methyl esterin heavydistillate of petroleum
The bulk container of test substance was inverted 10 times and a portion (500 mg) transferred to a vial. The entire contents of the vial were added directly to the sampling tank containing dispersant.
Results and discussion
- Mass median aerodynamic diameter:
- 252 µm
- Geometric standard deviation:
- 0
- Remarks on result:
- other: L-TME was determined to have d(0.1), d(0.5) and d(0.9) values of 63, 251 and 661 μm respectively. The Mass Median Diameter was determined to be 251 µm. No information on standard deviation.
Particle sizeopen allclose all
- Key result
- Percentile:
- D10
- Mean:
- 63 µm
- Remarks on result:
- other: No information for Standard deviation.
- Key result
- Percentile:
- D50
- Mean:
- 251 µm
- Remarks on result:
- other: No information for Standard deviation.
- Key result
- Percentile:
- D90
- Mean:
- 661 µm
- Remarks on result:
- other: No information for Standard deviation.
Any other information on results incl. tables
L-TME was determined to have d(0.1), d(0.5) and d(0.9) values of 63, 251 and 661 μm respectively.
Applicant's summary and conclusion
- Conclusions:
- The particle size distribution of L-TME was determined to have d(0.1), d(0.5) and d(0.9) values of 63, 251 and 661 μm respectively.
- Executive summary:
The size distribution of particles present in L-TME was assessed using particle size apparatus based on laser diffraction. L-TME was determined to have d(0.1), d(0.5) and d(0.9) values of 63, 251 and 661 μm respectively. The Mass Median Diameter was determined to be 251 µm
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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