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EC number: 233-153-9 | CAS number: 10045-95-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Based on the criteria as specified in the test report, the product existing of 75% lanthanum nitrate and 25% neodymium nitrate is classified as extremely irritating. Based on the criteria of the CLP Regulation, the substance is classified as Eye Dam 1 H318 based on the severe effects that have been observed. Reversibility is not expected.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2012-06-11
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Principles of method if other than guideline:
- Electrochemic determination of pH
Determination of the acidic reserve via titration - GLP compliance:
- yes
- Species:
- other: not applicable
- Strain:
- other: Not applicable
- Details on test animals or test system and environmental conditions:
- Not applicable
- Type of coverage:
- other: Not applicable
- Preparation of test site:
- other: Not applicable
- Vehicle:
- not specified
- Details on study design:
- Purpose:
The higher the buffer capacity of a mixture (solution or slurry) is, the stronger the irritating and corrosive potential is, respectively. The physiological effects of acidic or alkaline solutions are not only determined by the pH value but also by the buffering capacity. That is why it is necessary to determine the alkaline or acid reserve of identified products.
Method:
First, the pH-value of a 10% solution (or slurry) is determined electrochemically at 20°C with a calibrated pH meter (MA 235 Mettler Toledo). This value is recorded.
Determination of the acidic reserve titration:
- For the determination of the acid reserve: the titration volume (in mL) of a 1 mol/L NaOH solution, which is required to achieve a pH of 4 of a 10% solution (or slurry) at 20°C, is recorded.
Calculations:
Titration of the 10% solution/slurry
Acid reserve = titration volume [mL] x 0.4
A product is classified as corrosive if:
pH - 1/12 acid reserve <= -0.5 - Irritation / corrosion parameter:
- other: pH and acidic reserve
- Run / experiment:
- 1
- Value:
- 2.051
- Vehicle controls validity:
- not examined
- Negative controls validity:
- not examined
- Positive controls validity:
- not examined
- Remarks on result:
- no indication of irritation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The pH value of 10% solution of neodymium trinitrate was determined to be 2.07 and the acidic reserve 0.224. Based on these data, the calculation for corrosivity was 2.051 (> -0.5). Therefore the substance was considered not to be corrosive.
Not corrosive (based on an acidic reserve of and pH of 2.07, the calculation for corrosivity was 2.051 which is higher than -0.5)
Reference
A pH value of 2.07 was determined.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 10 March until 15 March 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study performed with a mixture of lanthanum trinitrate (75%) and neodymium trinitrate (25%), containing the following deviations: observation period limited to 7 days, limited details on test animals and conditions.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- observation period limited to 7 days instead of 21 days
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2 - 3 kg - Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL - Duration of treatment / exposure:
- 0.1 g of the product was instilled in the conjunctival sac of the left eye.
- Observation period (in vivo):
- 1 hour and 1, 2, 3, 4 and 7 days after instillation.
- Number of animals or in vitro replicates:
- 4
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): scoring was done if no washing done and if washing was done after 30 seconds. As the guideline prescribes a wash-out only after at least 24h, the scores of the eyes that were washed after 30s are not taken into account for the purpose of REACH.
SCORING SYSTEM: Draize scoring system, Kay and Calandra (1962) J. Soc. Cosmet. Chem. 13, 281: "Interpretation of eye-irritation tests" - Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 91.75
- Max. score:
- 110
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- of 4 animals
- Time point:
- 24/48/72 h
- Score:
- 2.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- of 4 animals
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- of 4 animals
- Time point:
- 24/48/72 h
- Score:
- 2.5
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- of 4 animals
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- probability of severe irritation
- Irritant / corrosive response data:
- Based on the scoring of Draize and Kay and Calandra, the substance was judged to be extremely irritating.
Other effects: iris scores increasing from 1 to 2 after 7 days in 3 of 4 animals and no pupil reflex; reduced pupil reflex from day 3 onwards; myosis after 1 h in 1 animal and after day 1 in all animals. - Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the criteria as specified in the test report, the product existing of 75% lanthanum nitrate and 25% neodymium nitrate is classified as extremely irritating. Based on the criteria of the CLP Regulation, the substance is classified as Eye Dam 1 H318 based on the severe effects that have been observed. Reversibility is not expected.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Based on the criteria as specified in the test report, the product existing of 75% lanthanum nitrate and 25% neodymium nitrate is classified as extremely irritating. Based on the criteria of the CLP Regulation, the substance is classified as Eye Dam 1 H318 based on the severe effects that have been observed. Reversibility is not expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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