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Diss Factsheets
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EC number: 608-605-7 | CAS number: 313482-99-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003-03-05 to 2003-03-13
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- only preliminary test using the flask method was performed, a main study using the column elution method was not performed because the analytical method is not sensitive enough to measure the water solubility accurately
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 1992
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed, 2002-07-09
- Type of method:
- flask method
- Specific details on test material used for the study:
- - Storage condition of test material: In the freezer protected from light, under nitrogen
- Water solubility:
- < 2 µg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- >= 1 - <= 168 h
- Temp.:
- 20.3 °C
- pH:
- >= 6.4 - <= 6.5
- Remarks on result:
- other: a main study using the column elution method was not performed because the analytical method is not sensitive enough (GC; LOQ 2 µg/L) to measure the water solubility
- Conclusions:
- The water solubility of the test substance at 20.3 +/- 0.6 °C is < 0.2 µg/L. The pH measured was 6.5.
Reference
Preliminary test
The mean recovery of the extraction procedure was determined to be 101 % (mean of 104 %, 103 % and 97 %) and 106 % (mean of 109 % and 103 %) at a test substance concentration of 0.1 and 0.5 mg/L in water, respectively. From this it was concluded that extraction of the test substance from samples is complete when using the sample hexane ratio of 10:1 (v/v) used in this study.
In chromatograms of blank double distilled water, a small response (corresponding to 0.4 mg/L) was observed. Because this response was not observed in chromatograms of hexane and the samples, it was assumed that something had gone wrong during pre-treatment of blank double distilled water.
In chromatograms for the 1 hour, 4 hours and 7 days stirred samples, no test substance was observed. Based on this, water solubility of the test substance is reported to be smaller than the limit of detection of the analytical method used. The limit of detection was determined to be 2 µg/L taking the concentration factor of the samples (10) into account.
The pH of the supernatant after 3 centrifugation steps was 6.5, 6.5 and 6.4 for the 1 hour, 4 hours and 7 days stirred water samples, respectively.
Main study
A main study using the column elution method was not performed because the analytical method is not sensitive enough to measure the water solubility accurately.
In conclusion, the water solubility of the test substance at 20.3 +/- 0.6 °C is < 0.2 µg/L.
Description of key information
The water solubility of the test substance at 20.3 +/- 0.6 °C is < 0.2 µg/L at pH 6.5 (limitation of the analytical method).
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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