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Diss Factsheets
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EC number: 945-920-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 30, 1964 - May 08, 1964
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Not a validated method for determining skin irritation or skin sensitisation, but provides reliable supporting information for “in-use” concentrations using a “standard practice” applied to ingredients for consumer formulations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The method followed in this study was that of the repeated insult method approved by the Food and Drug Administration.
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-methyl-4-(4-methylpentyl)cyclohex-3-ene-1-carbaldehyde
- EC Number:
- 266-314-7
- EC Name:
- 1-methyl-4-(4-methylpentyl)cyclohex-3-ene-1-carbaldehyde
- Cas Number:
- 66327-54-6
- Molecular formula:
- C14H24O
- IUPAC Name:
- 1-methyl-4-(4-methylpentyl)cyclohex-3-ene-1-carbaldehyde
- Reference substance name:
- 1-methyl-3-(4-methylpentyl)-3-Cyclohexene-1-carboxaldehyde
- Cas Number:
- 693252-50-5
- Molecular formula:
- C14H24O
- IUPAC Name:
- 1-methyl-3-(4-methylpentyl)-3-Cyclohexene-1-carboxaldehyde
- Reference substance name:
- Cyclohexanecarboxaldehyde, 1-methyl-4-(4-methylpentyl)-, trans-
- Cas Number:
- 76169-46-5
- Molecular formula:
- C14H26O
- IUPAC Name:
- Cyclohexanecarboxaldehyde, 1-methyl-4-(4-methylpentyl)-, trans-
- Reference substance name:
- Cyclohexanecarboxaldehyde, 1-methyl-4-(4-methylpentyl)-, cis-
- Cas Number:
- 76169-45-4
- Molecular formula:
- C14H26O
- IUPAC Name:
- Cyclohexanecarboxaldehyde, 1-methyl-4-(4-methylpentyl)-, cis-
- Reference substance name:
- 1-methyl-4-(4-methylpentylidene)cyclohexanecarbaldehyde
- Molecular formula:
- C14H24O
- IUPAC Name:
- 1-methyl-4-(4-methylpentylidene)cyclohexanecarbaldehyde
- Reference substance name:
- 1-methyl-4-(4-methyl-3-pentenyl)cyclohex-3-ene-1-carbaldehyde
- EC Number:
- 257-942-2
- EC Name:
- 1-methyl-4-(4-methyl-3-pentenyl)cyclohex-3-ene-1-carbaldehyde
- Cas Number:
- 52475-86-2
- Molecular formula:
- C14H22O
- IUPAC Name:
- 1-Methyl-4-(4-methylpent-3-en-1-yl)cyclohex-3-ene-1-carbaldehyde
- Reference substance name:
- 1-methyl-3-(4-methylpentylidene)cyclohexanecarbaldehyde
- Molecular formula:
- C12H24O
- IUPAC Name:
- 1-methyl-3-(4-methylpentylidene)cyclohexanecarbaldehyde
Constituent 1
Constituent 2
impurity 1
impurity 2
impurity 3
impurity 4
impurity 5
- Specific details on test material used for the study:
- Chemical A-7155 = Vernaldehyde
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Subjects:
- - A total of 55 healthy male and female inmate volunteers were screened and 52 completed the experiment.
- ages varied from 16 to 67 years
- No person was accepeted who had active dermatologic conditions or other indicated illness - Clinical history:
- No data
- Route of administration:
- dermal
- Details on study design:
- PRE-TEST:
In a pilot group with 10 subjects, the test material was applied in closed patch test to the medial surfaces of the left deltoid areas. 48 hours later, the patch was removed and te reading was recorded. 72 hour readings for possible delayed reactions were taken on the next day. When all the results were negative, it was considered safe to initiate the main study.
MAIN STUDY:
The procedure consists in the repeated application of closed patch tests with 0.5 mL of test material being applied to individual absorbent patch. The patch was then applied to the area to be tested in a consecutive order. The patch was then secured by means of overlying strips of adhesive tape which was then further sealed completely with additional overlying strips of similarly impervious tape. The patch was allowed to remain in situ for 48 hours and then removed, at which readings were recorded.
The initial site of application of the patch was the inner surface of the right deltoid area. When it was removed 48 hours after application, the next application was made to the inner surface of the left deltoid area. In turn, the next application was made to the upper portion of the right forearm and the following application to the volar surface of the upper portion of the left forearm. Upon completion of this cycle, a return to the inner surface of the right deltoid area was made. Subsequently, the cycle of rotation was continued until 10 similar test applications had been made.
Followed by a two week rest period after which the challenge test series was applied, to be removed for a 48 hour reading and a 72 hour reading for delayed reactions.
Results and discussion
- Results of examinations:
- No irritative reactions observed in any of the subjects during the sensitizing or challenge test phase.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of a repeated occlusive patch test procedure, the 2% test material 7155, produced no irritative reactions observed in any of the subjects during the sensitizing or challenge test phase.
Vernaldehyde produced no sensitisation reactions that were considered allergic in the volunteers tested
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