Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 278-051-5 | CAS number: 75005-95-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 OCtober 2020 to 15 July 2021
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 835.2120 (Hydrolysis of Parent and Degradates as a Function of pH at 25°C)
- Version / remarks:
- October 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Version / remarks:
- March 04, 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Version / remarks:
- April 13, 2004
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Physical Description: Colourless to pale yellow liquid (determined by Charles River Den Bosch)
Purity/Composition: 96.69%
Storage Conditions: At room temperature
Purity/Composition correction factor: No correction factor required
Test item handling: No specific handling conditions required
Chemical name : 2-Ethylhexyl 2-([1,1'-biphenyl]-4-ylcarbonyl)benzoate
CAS number: 75005-95-7
EC Number: 278-051-5
Molecular formula: C28H30O3
Molecular weight: 414.22 - Analytical monitoring:
- yes
- Details on sampling:
- Not reported.
- Buffers:
- - pH: 4, 7 and 9
- Type and final molarity of buffer: Acetate buffer pH 4, 0.01 M, Phosphate buffer pH 7, 0.01 M, Borate buffer pH 9, 0.01 M.
- Composition of buffer: pH 4: Solution of 16.7% 0.01 M sodium acetate in water and 83.3% 0.01 M acetic acid in water., pH 7: Solution of 0.01 M potassium di-hydrogen phosphate in water adjusted to pH 7 using 1N sodium hydroxide. Buffer contained 0.0009% (w/v) sodium azide.Buffer contained 0.0009% (w/v) sodium azide, pH 9: Solution of 0.01 M boric acid in water and 0.01 M potassium chloride in water adjusted to pH 9 using 1N sodium hydroxide. Buffer contained 0.0009% (w/v) sodium azide. - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: not reported
- Sterilisation method: not reported
- Lighting: test item placed in the dark.
- Measures taken to avoid photolytic effects: test item placed in the dark.
- Measures to exclude oxygen: To exclude oxygen, nitrogen gas was purged through the solution for 5 minutes.
- Details on test procedure for unstable compounds: not reported
- Details of traps for volatile, if any: not reported
- If no traps were used, is the test system closed/open: not reported
- Is there any indication of the test material adsorbing to the walls of the test apparatus?
TEST MEDIUM
- Volume used/treatment: 6 mL
- Kind and purity of water: buffer solutions
- Preparation of test medium: not reported
- Renewal of test solution: not reported
- Identity and concentration of co-solvent: acetonitrile
OTHER TEST CONDITIONS
- Adjustment of pH: not reported
- Dissolved oxygen: not reported - Duration:
- 5 d
- pH:
- 9
- Temp.:
- 19.9 °C
- Initial conc. measured:
- 17.3 µg/L
- Remarks:
- Experiment repeated at 30 °C and 50 °C.
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 20 °C
- Initial conc. measured:
- 17.2 µg/L
- Remarks:
- Experiment repeated at 30 °C and 50 °C.
- Duration:
- 5 d
- pH:
- 4
- Temp.:
- 20 °C
- Initial conc. measured:
- 16.2 µg/L
- Remarks:
- Experiment repeated at 30 °C and 50.1 °C.
- Number of replicates:
- 2
- Positive controls:
- not specified
- Negative controls:
- yes
- Statistical methods:
- Quantitative analysis was performed using Acquity UPLC system (Waters, Milford, MA, USA).
- Preliminary study:
- The buffer solutions were filter-sterilised through a 0.2 µm FP 30/0.2 CA-S filter (Whatman, Dassel, Germany) and transferred into a sterile vessel. To exclude oxygen, nitrogen gas was purged through the solution for 5 minutes. The test item was spiked to the solutions at a target concentration of 0.02 mg/L using a spiking solution in acetonitrile. For each sampling time, duplicate sterile vessels under vacuum were filled with 6 mL test solution and placed in the dark in a temperature controlled environment at 49.9°C ± 0.2°C.
The spiking volume was < 1% of the sample volume. Nominal concentrations were not corrected for the spiking volume.
The concentration of the test item in the test samples was determined immediately after preparation (t=0) and after 2.4 hours and 5 days.
Analysis was performed on subsamples of 250 µL. The samples were diluted in a 1:3 (v:v) ratio with acetonitrile and analyzed. The blank buffer solutions were diluted in a 1:3 (v:v) ratio with acetonitrile and analyzed.
Blank buffer solutions containing a similar content of blank spiking solution were treated similarly as the test samples and analyzed at t=0.
The pH of each of the test solutions (except for the blanks) was determined at each sampling time. - Transformation products:
- not measured
- % Recovery:
- 79
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- 78
- pH:
- 9
- Temp.:
- 30 °C
- Duration:
- 5 d
- % Recovery:
- 77
- pH:
- 9
- Temp.:
- 20 °C
- Duration:
- 5 d
- % Recovery:
- 70
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- 84
- pH:
- 7
- Temp.:
- 30 °C
- Duration:
- 5 d
- % Recovery:
- 83
- pH:
- 7
- Temp.:
- 20 °C
- Duration:
- 5 d
- % Recovery:
- 48
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- 63
- pH:
- 4
- Temp.:
- 30 °C
- Duration:
- 5 d
- % Recovery:
- 70
- pH:
- 4
- Temp.:
- 20 °C
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 20 °C
- DT50:
- 5.4 h
- pH:
- 7
- Temp.:
- 20 °C
- DT50:
- 5 h
- pH:
- 4
- Temp.:
- 20 °C
- DT50:
- 11 h
- Validity criteria fulfilled:
- yes
- Conclusions:
- The hydrolysis of the test item as a function of pH was calculated.
- Executive summary:
The objective of this study was to determine physico-chemical properties for the test item. The rate of hydrolysis of the test item as a function of pH was determined at pH values normally found in the environment (pH 4-9).
Reference
Information | Guideline(s) | Result | Comment |
Hydrolysis at pH 4 | EC C.7 OECD 111 OPPTS 835.2120 | t½ = 11 hours at 20°C t½ = 5.1 hours at 25°C t½ = 2.2 hours at 30°C t½ = 0.53 hours at 50°C | |
Hydrolysis at pH 7 | EC C.7 OECD 111 OPPTS 835.2120 | t½ = 5.0 hours at 20°C t½ = 3.1 hours at 25°C t½ = 1.9 hours at 30°C t½ = 0.39 hours at 50°C | |
Hydrolysis at pH 9 | EC C.7 OECD 111 OPPTS 835.2120 | t½ = 5.4 hours at 20°C t½ = 3.5 hours at 25°C t½ = 2.4 hours at 30°C t½ = 0.35 hours at 50°C |
Graphs appended to "attached documents".
Description of key information
Study conducted to recognised testing guidelines with GLP certification.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 11 h
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.