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Registration Dossier
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Diss Factsheets
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EC number: 209-162-9 | CAS number: 557-21-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- Zinc cyanide
- EC Number:
- 209-162-9
- EC Name:
- Zinc cyanide
- Cas Number:
- 557-21-1
- Molecular formula:
- Zn(CN)2
- IUPAC Name:
- ZINC DICYANIDE
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- ENVIRONMENTAL CONDITIONS: the animal room environment was automatically controlled according to KIT SOPs(target range: temperature 20±3°C, relative humidity 30-70%, approximatly 12 hours light/ 12 hours dark cycle with 150-300 Lux, and ventilation 10-20 times/hour). Temperature and relative humidity were monitored continuously. Animal room and cage cleaning was performed according to KIT SOPs. Cage card and animal room use record were attached on the cage and the entrance of the animal room, respectively.
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- shaved
- Vehicle:
- not specified
- Amount / concentration applied:
- 0.5g
- Observation period:
- 1, 24, 48 and 72 hours
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- No dermal irritation was observed at 1, 24, 48, 72 hours after test item application
- Other effects:
- Test item-related death or abnormal general clinical signs were not observed during the study period.
Test item-related body weight changes were not observed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- To investigate dermal irritation of the test item, Zinc cyanide was administered by dermal at dose of 0.5 g/head for 4 hours in 3 male New Zealand White rabbits. Mortality, clinical signs, body weight change and local irritation were observed until 72 hours after test item. No clinical sign, body weight, dead animaln or abnormal skin reaction considered to be due to test item were observed. In conclusion Zinc cyanide induced no dermal irritaiton in male New Zealand White rabbits and was considered to be a non-irritant.
- Executive summary:
For that endpoint, one reliable study to assess skin irritation and corrosion in vivo on the registered substance on New Zealand White rabbits was available. The study was performed according to the OECD Guideline 404 (Acute Dermal Irritation / Corrosion).
Under the experimental conditions, no skin reaction was observed with "Zinc cyanide batch n°10185145 " exposure. Therefore, "Zinc cyanide batch n°10185145" induced no dermal irritaiton in male New Zealand White rabbits and was considered to be a non-irritant.
The validity criteria were successful and the study was therefore regarded as acceptable for that endpoint.
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