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EC number: 208-753-9 | CAS number: 540-69-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Die akute und chronische Toxizität der Ameisensäure und ihrer Formiate)
- Author:
- G. MALORNY
- Year:
- 1 969
- Bibliographic source:
- ZERNAL Zeitschrift fuer Ernaehrungswissenschaft. (Dr. Dietrich Steinkopff Verlag, Postfach 111008, D-6100 Darmstadt 11, Fed. Rep. Ger.) V.1- 1960- Volume(issue)/page/year: 9,332,1969
Materials and methods
Test guideline
- Guideline:
- other: Study conducted prior to implementation of GLP and OECD guidelines
- Principles of method if other than guideline:
- Study conducted prior to implementation of GLP and OECD guidelines
- GLP compliance:
- no
- Remarks:
- data published prior to implementation of GLP
- Test type:
- standard acute method
Test material
- Reference substance name:
- Ammonium formate
- EC Number:
- 208-753-9
- EC Name:
- Ammonium formate
- Cas Number:
- 540-69-2
- Molecular formula:
- CH2O2.H3N
- IUPAC Name:
- ammonium formate
- Test material form:
- solid: crystalline
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- oral application of doses up to the range of 2050- 2460mg/kg bw where LD50 values were determined.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- up to 2050 - 2460 mg/ kg bw
- No. of animals per sex per dose:
- 50
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 250 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 50 % Mortality was observed
- Clinical signs:
- other: Details of toxic effects not reported other than lethal dose value
Any other information on results incl. tables
Beside the determination of the LD50 of ammonium formate the LD50 of fomate ion was calculated to be 1610 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- According to the study of Malorny (1969) the LD50 of ammonium formate was determined in mice at a dose of 2250 mg/kg bw after oral administration. No other signs of toxicity were reported.
Based on the Globally Harmonized System for Classification and Labelling of Chemicals (GHS) Ammonium formate has to be categorized as Category 5 "May be harmful if swalloed", according to Regulation (EC) No 1272/2008 Ammonium formate does not need to be classified for acute oral toxicity. - Executive summary:
In an acute oral toxicity study conducted prior to implementation of OECD and GLP Guidelines but comparable to OECD guideline 401, in sum 50 mice were given a single oral dose of Ammonium formate by gavage at doses up to 2050 - 2460mg/kg bw. No other adverse effects were described.
Oral LD50 (mice) =2250 mg/kg bw
Based on the Globally Harmonized System for Classification and Labelling of Chemicals (GHS) Ammonium formate has to be categorized as Category 5 "May be harmful if swalloed", according to Regulation (EC) No 1272/2008 Ammonium formate does not need to be classified for acute oral toxicity.
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