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Diss Factsheets
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EC number: 423-860-2 | CAS number: 56309-94-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Vehicle:
- not specified
- Test organisms (species):
- Daphnia magna
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Nominal and measured concentrations:
- Nominal concentration: 100 mg/L
Means measured concentration: 73 mg/L - Details on test conditions:
- TEST SYSTEM
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
TEST MEDIUM / WATER PARAMETERS
- Preparation of dilution water: according to OECD 202
EFFECT PARAMETERS MEASURED
mortality and mobility after 24 and 48h
RANGE-FINDING STUDY
- Test concentrations: not available
- Results used to determine the conditions for the definitive study: yes, no mortalily up to 100 mg/L - Reference substance (positive control):
- not specified
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 73 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 73 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities:
no
- Observations on body length and weight: no
- Other biological observations: no
- Mortality of control: no
- Other adverse effects control: no
- Immobilisation of control: no
- Abnormal responses: no
- Any observations that might cause a difference between measured and nominal values: no
- Effect concentrations exceeding solubility of substance in test medium: no
The analytical program showed that the actual concentration could be maintained at more than 80 % of the initial concentration. The measured concentration was almost 30% lower than the prepared concentration, probably owing to the method of sample treatment which included an extraction procedure. - Validity criteria fulfilled:
- yes
- Conclusions:
- The test item showed no toxicity towards Daphnia according to OECD 202 up to 73 mg/L (NOEC=73 mg/L, LC50> 73 mg/L mean measured concentration).
- Executive summary:
The objective of the study was to determine the acute toxicity of the test item using Daphnia magna according to OECD 202 and EU Method C.2. For this purpose, juvenile Daphnia magna were exposed to an aqueous test material solution over 48 hours under defined conditions. The study comprised of two test vessels per concentration containing ten Daphnia magna each, i.e. 20 Daphnia magna per concentration (test medium group) and control group. Daphnia were exposed to a nominal test material concentration of 100 mg/L (limit test) in an open static system. The measured concentration was almost 30% lower than the prepared concentration, probably owing to the method of sample treatment which included an extraction procedure. Therefore the results are based on the mean measured concentration. Daphnia magna exposed to an aqueous preparation of the nominal concentration of 100 mg/L were not affected. For the test material, the following EC50 values for Daphnia magna were determined: 48h-EC50: > 73 mg/L mean measured concentration, NOEC = 73 mg/L.
Reference
Description of key information
The test item showed no toxicity towards Daphnia according to OECD 202 up to 73 mg/L (NOEC=73 mg/L, LC50> 73 mg/L mean measured concentration, reference 6.1.3 -1).
Key value for chemical safety assessment
Additional information
The objective of the study was to determine the acute toxicity of the test item using Daphnia magna according to OECD 202 and EU Method C.2. For this purpose, juvenile Daphnia magna were exposed to an aqueous test material solution over 48 hours under defined conditions. The study comprised of two test vessels per concentration containing ten Daphnia magna each, i.e. 20 Daphnia magna per concentration (test medium group) and control group. Daphnia were exposed to a nominal test material concentration of 100 mg/L (limit test) in an open static system. The measured concentration was almost 30% lower than the prepared concentration, probably owing to the method of sample treatment which included an extraction procedure. Therefore the results are based on the mean measured concentration. Daphnia magna exposed to an aqueous preparation of the nominal concentration of 100 mg/L were not affected. For the test material, the following EC50 values for Daphnia magna were determined: 48h-EC50: > 73 mg/L mean measured concentration, NOEC = 73 mg/L (reference 6.1.3 -1).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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