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Diss Factsheets
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EC number: 431-540-9 | CAS number: 170573-32-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dissociation constant
Administrative data
- Endpoint:
- dissociation constant
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- the study does not need to be conducted because the substance has no ionic structure
- Justification for type of information:
- The test substance is poorly soluble in water.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- water solubility
- Remarks:
- Critical micelle concentration (CMC)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Justification for type of information:
- The critical micelle concentration (CMC) is considered more appropriate for chemicals with surface-active properties.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Type of method:
- other: determination of critical micelle concentration (CMC)
- Key result
- Water solubility:
- 8.5 mg/L
- Conc. based on:
- other: CMC
- Remarks on result:
- other: no further details
- Conclusions:
- Under the study conditions, the water solubility (CMC) of the test substance was determined to be 8.5 mg/L.
- Executive summary:
A study was conducted to determine the water solubility of the test substance according to OECD Guideline 105 and EU Method A.6. In a previous experiment with the shake flask method, the water solubility was determined to be below the limit of quantification (<3.46 × 10 -3 g/L) (Tognucci, 1999). The critical micelle concentration (CMC) was therefore considered to be more appropriate for this test substance which presents surface-active properties. A study by inverse CMC measurement (plate method) was conducted, and the CMC was calculated by plotting surface tension against concentration. Under the study conditions, the water solubility (CMC) of the test substance was determined to be 8.5 mg/L (RCC, 1999).
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- From April 26, 1999 to June 07, 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- Batch no.: E 16734
Purity: 100%
Appearance: liquid to paste - Key result
- Water solubility:
- < 3.46 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 160 other: mg in 50 mL
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- 5
- Remarks on result:
- other: below the limit of determination
- Details on results:
- The quantification of the test substance amount was limited by the LOQ (limit of quantification) which was 3.46 mg/L during this study. The test substance could not be detected in any of the equilibrated samples. In conclusion, the water solubility of the test substance at 20°C +/- 0.5°C was determined to be below the limit of determination which was ca. 3.46 mg/L.
- Conclusions:
- Under the study conditions, the water solubility of the test substance was below the limit of determination which was ca. 3.46 mg/L, at 20°C (flask method).
- Executive summary:
A study was conducted to determine the water solubility of the test substance according to OECD Guideline 105 and EU Method A.6 (flask method), in compliance with GLP. About 160 mg of test substance was weighed into each of 6 Erlenmeyer flasks and 50 mL of water were added to each flask. The tightly closed flasks were shaken at about 30°C for 24, 48 and 72 h, respectively. Afterwards, the flasks were equilibrated for another 24 h at 20 +/- 0.5°C. The supernatant solutions were centrifuged (-2900 g), filtered (0.45 µm) and measured without dilution. The quantification was performed using a HPLC method. The quantification of the test substance was limited by the LOQ (limit of quantification) which was 3.46 mg/L. The test substance could not be detected in any of the equilibrated samples. In conclusion, under the study conditions, the water solubility of the test substance at 20°C +/- 0.5°C was determined to be below the limit of determination which was ca. 3.46 mg/L (Tognucci, 1999).
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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