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EC number: 422-460-5 | CAS number: 137234-87-8 UK-103,442
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 1998-11-11 to 1998-11-18
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Batch No.: 960509
Purity: 92.3% - Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling method:
After the test solution prepared, an aliquot (ca 30 mL) of each solution was poured into a stoppered bottle and placed in the 20°C water bath for approximately 5 minutes prior to analysis.
After 2.4 hours and 5 days, an aliquot (ca 30 mL) of each solution was taken and cooled to 20°C prior to analysis.
- Sampling intervals/times for pH measurements: At the end of the five day test period, the pH of the remainder of each test solution was measured at 50°C. - Buffers:
- - pH: 4, 7 & 9
PREPARATION OF BUFFER SOLUTIONS
- pH 4 buffer:
0.1M potassium hydrogen phthalate solution was adjusted to pH 4.0 with 1M hydrochloric acid, with the temperature of the buffer solution at 50°C ± 0.5°C.
- pH 7 buffer:
0.1M potassium dihydrogen orthophosphate solution was adjusted to pH 7.0 with 1M sodium hydroxide, with the temperature of the buffer solution at 50°C ± 0.5°C.
- pH 9 buffer:
0.1M solution of potassium chloride and boric acid was adjusted to pH 9.0 with 1M sodium hydroxide, with the temperature of the buffer solution at 50°C ± 0.5°C. - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: 100 mL volumetric flasks
- Sterilisation method: Prior to the test, the volumetric flasks were rinsed with ethanol and allowed to drip dry
- Measures taken to avoid photolytic effects: flasks were covered in aluminium foil to exclude light
- If no traps were used, is the test system: closed
TEST MEDIUM
- Volume used/treatment: 100 mL
- Preparation of test medium: The buffer solutions were autoclaved at 122°C for 17 minutes and then purged with nitrogen for 10 minutes prior to use.
- Renewal of test solution: not renewed
OTHER TEST CONDITIONS
- Adjustment of pH: no - Number of replicates:
- 2
- Negative controls:
- yes
- Remarks:
- Flasks containing buffer solution only (one at each pH) were treated in the same manner as with the test solutions.
- Preliminary study:
- No hydrolysis was observed under the test conditions at any pH.
0.3, 0.5, 0.9% hydrolysis occurring in 5 days at 50°C at pH 4, 7, 9, respectively.
0.2, 0, 0% hydrolysis occurring in 2.4 hours at 50°C at pH 4, 7, 9, respectively. - Transformation products:
- not measured
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test item possesses half-life times of greater than 1 year at pH 4, 7 and 9 at 25°C.
- Executive summary:
The study was performed to obtain estimates of the rate of hydrolysis of the test item under pH conditions relevant to the environment. The test was performed in accordance with the preliminary test as described in the OECD Method 111.
After a period of 5 days at 50°C, the test item underwent no significant hydrolysis at pH 4, 7 and 9.
The results indicate that at 25°C, the test item will possess half-life times of greater than 1 year at pH 4, 7 and 9.
Reference
Description of key information
The study was performed to obtain estimates of the rate of hydrolysis of the test item under pH conditions relevant to the environment. The test was performed in accordance with the preliminary test as described in the OECD Method 111.
After a period of 5 days at 50°C, the test item underwent no significant hydrolysis at pH 4, 7 and 9.
The results indicate that at 25°C, the test item will possess half-life times of greater than 1 year at pH 4, 7 and 9.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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