Magnesium perchlorate

Endpoint summary

Key value for chemical safety assessment

Genetic toxicity in vitro

Description of key information

in vitro, AMES: negative (prediction by OECD QSAR Toolbox v4.3.1, 2019; based on experimental result (OECD TG 471, GLP) of the closely related analogue Lithium perchlorate)

Link to relevant study records

Reference

Endpoint:

in vitro gene mutation study in bacteria

Remarks:

in silico, (Q)SAR performed with OECD QSAR Toolbox, Read Across analysis

Type of information:

other: (Q)SAR from supporting substances (structural analogues or surrogates) for which an experimental result is available

Adequacy of study:

key study

Study period:

2019-03-29

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification, with an experimental result (as provided by the OECD QSAR Toolbox)

Justification for type of information:

1. SOFTWARE
OECD QSAR Toolbox v4.3.1

2. MODEL (incl. version number)
Read Across analysis

3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
[Mg+2].[O-]Cl(=O)(=O)=O.[O-]Cl(=O)(=O)=O

4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
Please refer to 'Attached justification'

5. APPLICABILITY DOMAIN
Please refer to 'Attached justification'

Guideline:

other: ECHA Guidance R.6

Principles of method if other than guideline:

- Software tool(s) used including version: OECD QSAR Toolbox v4.3.1
- Model(s) used: Read Across analysis
- Model description: see field 'Justification for non-standard information' and 'Attached justification'
- Justification of QSAR prediction: see field 'Justification for type of information' and 'Attached justification'

GLP compliance:

not specified

Remarks:

Not applicable (QSAR calculation

Type of assay:

bacterial reverse mutation assay

Specific details on test material used for the study:

[Mg+2].[O-]Cl(=O)(=O)=O.[O-]Cl(=O)(=O)=O

Species / strain / cell type:

S. typhimurium TA 1535

Species / strain:

S. typhimurium TA 1535

Metabolic activation:

not applicable

Genotoxicity:

negative

Cytotoxicity / choice of top concentrations:

not determined

Vehicle controls validity:

not applicable

Untreated negative controls validity:

not applicable

True negative controls validity:

not applicable

Positive controls validity:

not applicable

Remarks on result:

no mutagenic potential (based on QSAR/QSPR prediction)

Conclusions:

The genetic toxicity of Magnesium perchlorate was predicted with OECD QSAR Toolbox v4.3.1 using experimental results of the analogue Lithium perchlorate (CAS 7791-03-9). Since the perchlorate is considered to trigger the toxicity, this approach is justified. The prediction is negative.

Predictions by the OECD QSAR Toolbox v4.3.1 with experimental result(s) of closely related perchlorate with CAS 7791-03-9 contained therein are used to address the endpoint, which is entirely appropriate to draw conclusions on the genetic toxicity of Magnesium perchlorate.

Executive summary:

The genetic toxicity of Magnesium perchlorate was predicted with OECD QSAR Toolbox v4.3.1 using experimental results of the analogue Lithium perchlorate (CAS 7791-03-9). Since the perchlorate is considered to trigger the toxicity, this approach is justified. The prediction is negative.

Predictions by the OECD QSAR Toolbox v4.3.1 with experimental result(s) of closely related perchlorate with CAS 7791-03-9 contained therein are used to address the endpoint, which is entirely appropriate to draw conclusions on the genetic toxicity of Magnesium perchlorate.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (negative)

Genetic toxicity in vivo

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

Genetic toxicity of Magnesium perchlorate was predicted with OECD QSAR Toolbox v4.3.1 using experimental results of the closely analogue substance Lithium perchlorate (CAS 7791-03-9). This analogue substance was tested in vitro for its genetic toxicity according to OECD TG 471 (GLP). Since the perchlorate is considered to trigger the toxicity, this approach is justified and considered as entirely appropriate to draw conclusions on the genetic toxicity of Magnesium perchlorate. However, the registrant is prepared to conduct an experimental study but considered it as not necessary at first instance taking into account the available results.

Justification for classification or non-classification

Magnesium perchlorate was predicted to be not mutagenic by OECD QSAR Toolbox v4.3.1, based on in vitro results (AMES) of the closely analogue substance Sodium perchlorate. Hence, Magnesium perchlorate does not require classification according to Regulation (EC) No. 1272/2008.