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EC number: 680-227-5 | CAS number: 71449-78-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 August 2008 - 27 August 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Version / remarks:
- 2001
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 bis (Acute Oral Toxicity - Fixed Dose Procedure)
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Diphenyl[4-(phenylsulfanyl)phenyl] sulfonium hexafluoroantimonate(1-)
- EC Number:
- 680-227-5
- Cas Number:
- 71449-78-0
- Molecular formula:
- C24H19F6S2Sb
- IUPAC Name:
- Diphenyl[4-(phenylsulfanyl)phenyl] sulfonium hexafluoroantimonate(1-)
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Storage condition of test material: Room temperature in the dark.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Remarks:
- CDtm
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Limited, Bicester, Oxon, UK
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: 8 - 12 weeks
- Weight at study initiation: body weight variation did not exceed ±20% of the mean body weight at the start of treatment
- Fasting period before study: yes 24hrs before dosing and 3 -4 hours after dosing
- Housing: housed in groups of up to 4 individuals in suspended solid-floor polypropylene cages furnished with woodflakes.
- Diet (e.g. ad libitum): free access to food (certified rat and mouse diet)
- Water (e.g. ad libitum): free access to mains drinking water
- Acclimation period: minimum of 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 25 ºC
- Humidity (%): 30 - 70 %
- Air changes (per hr): minimum of 15 changes per hour
- Photoperiod (hrs dark / hrs light): 12 : 12
IN-LIFE DATES: From: Not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- DMSO
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: DMSO
- Amount of vehicle (if gavage): not specified
- Justification for choice of vehicle:The test item did not dissolve /suspend in distilled water or arches oil BP
- Lot/batch no. (if required): not specified
- Purity: not stated
MAXIMUM DOSE VOLUME APPLIED: 10.0 mL/kg
DOSAGE PREPARATION (if unusual): the test item was dissolved in DMSO at concentration of 200 mg/ml and dose volume of 10 ml/kg.
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: maximum guideline required concentration - 2000 mg/kg - Doses:
- 2000 & 300 mg/kg
- No. of animals per sex per dose:
- 1 for 2000 mg/kg, 5 for 300 mg/kg
- Control animals:
- no
- Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 0.5, 1, 2 and 4 hours after dosing then daily thereafter.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and body weight on day 0, 7 and 14 - Statistics:
- Not required
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: death observed at higher dose of 2000 mg/kg bw/day
- Mortality:
- One animal at 2000 mg/kg bw/day was killed in extremis four hours after dosing and one animal found dead at 300 mg/kg bw/day on day one of dosing.
- Clinical signs:
- other: At 2000 mg/kg bw/day: the following were observed; hunched posture, ataxia, pilo-erection, laboured respiration, decreased respiration, gasping respiration and hypothermia. At 300 mg/kg bw/day, hunched posture, ataxia, pilo-erection, lethargy and diuresi
- Gross pathology:
- Necropsy at 300 mg/kg bw/day, abnormalities noted included; abnormally red lungs, dark liver and dark kidneys. No abnormalities were noted in the animal killed in extremis or killed at the end of the study.
Any other information on results incl. tables
Table 2 Number of animals dead (and with evident of toxicity)
Dose (mg/kg bw) |
Mortality (# dead / total) |
Time range of deaths (hours) |
Number with evident toxicity (# / total) |
||||
Male |
Female |
Combined |
Male |
Female |
Combined |
||
2000 |
- |
1/ 1 |
1/ 1 |
4hr post dosing |
- |
1/ 1 |
1 / 5 |
300 |
- |
1 / 5 |
1 / 5 |
Day 1 of dosing |
- |
1 / 5 |
1 / 5 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The test item met the criteria for classification of acute toxicity category 4 according to Regulation (EC) No. 1272/2008 on the Classification, Labelling and Packaging of Substances and Mixtures.
- Executive summary:
OECD 420 (2008) - In an acute oral toxicity study, a group of fasted, 8-12 week old female Wistar rats were given a single oral dose of the test item, CPI-110A at a single dose rate of 2000 mg/kg bw (limit test), after observation of mortality another animal was dosed at 300 mg/kg bw/day and in the absence of mortality, further dosing at similar dosing was conducted in 4 other animals followed by observed for 14 days.
One animal at 2000 mg/kg bw/day was killed in extremis four hours after dosing and one animal found dead at 300 mg/kg bw/day on the day one of dosing.
At 2000 mg/kg bw/day: the following were observed; hunched posture, ataxia, pilo-erection, laboured respiration, decrease respiration, gasping respiration and hypothermia. At 300 mg/kg bw/day, hunched posture, ataxia, pilo-erection, lethargy and diuresis.
In addition, there were no treatment related clinical signs, necropsy findings or changes in body weight observed in any of the other animals. All animals showed expected gains in body weight over the observation period.
Necropsy at 300 mg/kg bw/day, abnormalities noted included; abnormally red lungs, dark liver and dark kidneys. No abnormalities were noted in the animal killed in extremis or killed at the end of the study.
Based on condition of the study, the acute oral lethal dose (LD50) of the test item was estimated to be > 300 mg/kg bw/day (GHS classification of category 4). The test item met the criteria for classification of acute toxicity category 4 according to Regulation (EC) No. 1272/2008 on the Classification, Labelling and Packaging of Substances and Mixtures.
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