m-bis(2,3-epoxypropoxy)benzene

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Data source

Reference

Reference 1

Reference Type:

publication

Title:

The Toxicology of Epoxy Resins

Author:

Hine CH, Kodama JK, Anderson HH, Simonson DW, Wellington JS.

Year:

1958

Bibliographic source:

AMA Archives of Industrial Health

Reference 2

Reference Type:

publication

Title:

The Toxicology of Glycidol and Some Glycidyl Ethers

Author:

Hine CH, Kodama JK, Wellington JS, Dunlap MK, Anderson HH

Year:

1956

Bibliographic source:

AMA Arch Indust Health 14:250-264

Reference 3

Reference Type:

publication

Title:

Toxicology and safe handling of CBP-55 (Technical 1-chloro-3-romopropene-1)

Author:

Hine CH, Anderson HH, Moon HD, Kodama JK, Morse M, Jacobsen NW

Year:

1953

Bibliographic source:

AMA Arch Indust Hyg, 7: 118-136

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Groups of six rats were exposed to saturated vapors of diclycidyl resorcinol at 30±1 °C within 8 hours, by passage through the liquids in two fritted glass bubblers connected in series in a glass chamber of 19.5 L capacity. The motor-driven syringe assembly delivered measured amounts of the test compound from a 10 mL. Luer-Lok syringe into an evaporator through which metered air moved at a uniform rate. The air flow was set at approximately 3 to 11 L per minute, depending on the concentration desired. Nominal concentrations were calculated by the standard gas-concentration formula of Jacobs and were checked by determining the total quantity of material vaporized.

GLP compliance:

no

Remarks:

pre-GLP

Test type:

other: 8-hour exposure to saturated vapors (the maximum attainable concentration)

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

m-bis(2,3-epoxypropoxy)benzene

EC Number:

202-987-5

EC Name:

m-bis(2,3-epoxypropoxy)benzene

Cas Number:

101-90-6

Molecular formula:

C12H14O4

IUPAC Name:

2-({3-[(oxiran-2-yl)methoxy]phenoxy}methyl)oxirane

Test material form:

liquid: viscous

Test animals

Species:

rat

Strain:

Long-Evans

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: commercial laboratory in Gilroy, California
- Weight at study initiation: 110-150 g
- Housing: six to a cage
- Diet: standard laboratory pellets
- Water: tap water
- Acclimation period: for about two weeks

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 14 and 18

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Motor-driven syringe assembly: Luer-Lok syringe into an evaporator through which metered air moved at a uniform rate
- Exposure chamber volume: 19.5 L
- Method of holding animals in test chamber: 6 animals/chamber
- Method of conditioning air: high concentration was obtained by bubling air through a fritted glass disc immersed in the compound, which was held in a glass container
- Source and rate of air: air flow was set at 3 to 11 L/min, depending on the concentration desired
- Temperature, humidity, pressure in air chamber: 30±1 °C

Analytical verification of test atmosphere concentrations:

no

Remarks:

the concentration was too low to permit accuracy of determination

Duration of exposure:

8 h

Concentrations:

saturated vapour of diglycidyl resorcinol

No. of animals per sex per dose:

6 males

Control animals:

no

Details on study design:

- Duration of observation period following administration: 10 days
- Frequency of observations and weighing: noted weighing changes
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross pathology

Statistics:

one level tested

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

other:

Remarks:

the maximum attainable concentration

Effect level:

other: the maximum attainable concentration

Based on:

test mat.

Exp. duration:

8 h

Remarks on result:

not determinable due to absence of adverse toxic effects

Mortality:

Not reported

Clinical signs:

other: Not reported

Body weight:

Not reported

Gross pathology:

Not reported

Other findings:

No systemic toxicity has resulted from inhalation of the saturated vapours

Applicant's summary and conclusion

Interpretation of results:

other: no toxicity hazard could be associated at the maximum attainable concentration

Conclusions:

The test item diglycidyl resorcinol does not need to be classified as no toxicity hazard could be associated at the maximum attainable concentration.

Executive summary:

The six rat males of the Long-Evans strain (bw 110 -150 g) were exposed with the saturated vapor of diglycidyl resorcinol for eight hours.

The authors concluded that no practical toxicity hazard could be associated.