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EC number: 816-856-0 | CAS number: 5205-01-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-09-25 to 2018-10-18
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- No samples were used from the test. The test substance was analytical verified via a separate analytic in Daphnia medium at concentrations of 2, 20, 30 and 40 mg/L.
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Controls and Treatment: 5 daphnids per replicate, 4 replicates in total - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna straus, Crustacean, Cladocero
- Source: Eurofins Biolab Test Facility
- Age of parental stock (mean and range, SD): 6-24 hours (Breeder)
- Feeding during test: No
ACCLIMATION
- Acclimation conditions (same as test or not): Same as test
- Type of food: Green alga, Pseudokirchneriella subcapitata and Saccharomices cerevisiae
- Health during acclimation (any mortality observed): No - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 140 - 250 mg CaCO3/L
- Test temperature:
- 20 - 20.2°C
- pH:
- Control: 8.04 - 7.78
Treatment: 8.01 - 7.77 - Dissolved oxygen:
- Control: 5.44 - 6.20 mg/L
Treatment: 5.77 - 6.02 mg/L - Nominal and measured concentrations:
- Nominal: 0 and 100 mg/L
Measured: 0 and 106 mg/L (0h); 0 and 102 mg/L (48h) - Details on test conditions:
- TEST SYSTEM
- Test vessel: Glass beaker
- Type (delete if not applicable): open
- Aeration: None
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
OTHER TEST CONDITIONS
- Adjustment of pH: No.
- Photoperiod: None in the course of the test.
- Light intensity: No lightning in the course of the test.
RANGE-FINDING STUDY
- Test concentrations: Ten-fold dilutions from 1000 mg/L to 0.1 mg/L.
- Results used to determine the conditions for the definitive study: Yes - Reference substance (positive control):
- no
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
- Conclusions:
- The toxicity of 3-methyl-1,3-butandiol acetate was determined in an OECD 202 study with Daphnia magna and in compliance with GLP. Daphnids were exposed to the test substance in a concentration of 100 mg/L for 48h. Test concentration was analytically verified via GC-FID. No immobility of Daphnids were observed after 24 and 48h. The EC50 value after 24 and 48h was determined with > 100 mg/L based on nominal concentration.
Reference
Table 1: Number of immobilised Daphnia at 24 and 48 hours in the control and in the treated groups (test item)
Control |
24 hours |
48 hours |
Control replication N.1 |
0/5 |
0/5 |
Control replication N.2 |
0/5 |
0/5 |
Control replication N.3 |
0/5 |
0/5 |
Control replication N.4 |
0/5 |
0/5 |
Concentration 1: 100 mg/L |
24 hours |
48 hours |
Treated -replication N.1 |
0/5 |
0/5 |
Treated -replication N.2 |
0/5 |
0/5 |
Treated -replication N.3 |
0/5 |
0/5 |
Treated -replication N.4 |
0/5 |
0/5 |
Description of key information
EC50 (24h) = > 100 mg/L
EC50 (48h) = > 100 mg/L
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
The toxicity of 3-methyl-1,3-butandiol acetate was determined in an OECD 202 study with Daphnia magna and in compliance with GLP. Daphnids were exposed to the test substance in a concentration of 100 mg/L for 48h. Test concentration was analytically verified via GC-FID. No immobility of Daphnids were observed after 24 and 48h. The EC50 value after 24 and 48h was determined with > 100 mg/L based on nominal concentration.
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