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EC number: 241-510-5 | CAS number: 17501-44-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 Feb 2020 - 10 Apr 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- December 2001
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Version / remarks:
- December 2002
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Version / remarks:
- May 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Appendix to Director General Notification, No. 12-Nousan-8147. Agricultural Production Bureau, Ministry of Agriculture, Forestry and Fisheries of Japan (JMAFF)
- Version / remarks:
- November 2000, including the most recent revisions
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Tetrakis(pentane-2,4-dionato-O,O')zirconium
- EC Number:
- 241-510-5
- EC Name:
- Tetrakis(pentane-2,4-dionato-O,O')zirconium
- Cas Number:
- 17501-44-9
- Molecular formula:
- C20H28O8Zr
- IUPAC Name:
- 2,4,8,8,10,10,13,15-octamethyl-1λ³,5λ³,7λ³,7λ³,11λ³,11λ³,12λ³,16λ³-octaoxa-6-zirconadispiro[5.5⁶.5⁶.5⁶]henicosa-1,4,7,7,10,10,12,15-octaene-6,6,6,6-tetrakis(ylium)-3,9,9,14-tetraide
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Identification: Zirconium (IV) acetylacetonate (Zr-acac)
- Description: White to off-white powder
- Storage conditions: At room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- Crl: WI(Han)
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland, Sulzfeld, Germany
- Females nulliparous and non-pregnant: yes
- Age at study initiation: approximately 8-9 weeks old
- Weight at study initiation: 149 to 179 g
- Fasting period before study: Animals were deprived of food overnight (for a maximum of 20 hours) prior to dosing and until 3-4 hours after administration of the test item.
- Housing: Animals were group housed (up to 3 animals of the same sex and same dosing group together) in polycarbonate cages
- Diet: ad libitum, pelleted rodent diet (SM R/M-Z from SSNIFF® Spezialdiäten GmbH, Soest, Germany)
- Water: ad libitum, municipal tap-water
- Acclimation period: at least 5 days
- Microbiological status: SPF-Quality
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-21
- Humidity (%): 36-53
- Air changes (per hr): ≥10
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 05 Mar 2020 To: 10 Apr 2020
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- propylene glycol
- Details on oral exposure:
- VEHICLE
- Justification for choice of vehicle: Trial preparations were performed to select the suitable vehicle and to establish a suitable formulation procedure.
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg
DOSAGE PREPARATION:
Test item dosing formulations (w/w) were homogenized to visually acceptable levels at appropriate concentrations to meet dose level requirements.
The dosing formulations were kept at room temperature until dosing. The dosing formulations were stirred until and during dosing.
An adjustment was made for specific gravity of the vehicle (specific gravidity propylene glycol: 1.036). No correction was made for the purity/composition of the test item.
CLASS METHOD
- Rationale for the selection of the starting dose: The starting dose level was selected based on available toxicity data of the test item. - Doses:
- The first group was treated at a dose level of 300 mg/kg. Based on the results, two additional groups were dosed, one at 2000 mg/kg and one at 300 mg/kg.
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Post-dose observations were performed at periodic intervals on the day of dosing (at least three times) and once daily thereafter. Animals were weighed individually on Day 1 (pre-dose), 8 and 15. A fasted weight was recorded on the day of dosing.
- Necropsy of survivors performed: yes, descriptions of all internal macroscopic abnormalities were recorded. - Statistics:
- Not performed
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- At 2000 mg/kg, all animals were found dead on Day 1 post-treatment.
At 300 mg/kg, no mortality occurred. - Clinical signs:
- other: At 2000 mg/kg hunched posture, erected fur, moderate salivation, abnormal respiratory rate, lying on the side and decreased activity was noted for all animals on day 1. At 300 mg/kg hunched posture and erected fur was noted for all six animals on Day 1 an
- Gross pathology:
- No test item related abnormalities were found at macroscopic post mortem examination of the animals. Abnormalities of the kidney (dilatation bilateral) and the thymus (focus dark red multifocal) were found in one animal that died during the study, however, these findings are more often seen in rats of this strain in this type of study and therefore no toxicological relevance was attached to these findings.
Applicant's summary and conclusion
- Interpretation of results:
- other: acute tox. 4
- Remarks:
- according to Regulation (EC) No 1272/2008
- Conclusions:
- In an acute oral toxicity study in Wistar Han rats according to OECD TG 423 the oral LD50 value of Zirconium (IV) acetylacetonate (Zr-acac) was established to be within the range of 300-2000 mg/kg body weight.
- Executive summary:
An acute oral toxicity study was performed in rat according to OECD TG 423 and in accordance with GLP principles. Initially, Zirconium (IV) acetylacetonate (Zr-acac) was administered by oral gavage to three
female Wistar Han rats at 300 mg/kg body weight. In a stepwise procedure two additional groups of three females were dosed, one at 2000 mg/kg and one at 300 mg/kg body weight. All animals were subjected to daily observations and weekly determination of body weight. Macroscopic examination was performed on the day of death or after terminal sacrifice (day 15).
At 2000 mg/kg, all animals were found dead on Day 1 post-treatment. At 300 mg/kg, no mortality occurred.
At 2000 mg/kg, hunched posture, erected fur, moderate salivation, abnormal respiratory rate, lying on the side and decreased activity was noted for all animals on day 1. At 300 mg/kg, hunched posture and erected fur was noted for all six animals on day 1 and for three animals also between days 2 and 4. The body weight gain shown by the surviving animals over the study period was considered
to be similar to that expected for normal untreated animals of the same age and strain. No test item related abnormalities were found at macroscopic post mortem examination of the animals.
The oral LD50 value of Zirconium (IV) acetylacetonate (Zr-acac) in Wistar Han rats was established to be within the range of 300-2000 mg/kg body weight.
According to OECD TG 423 test guideline, the LD50 cut-off value was considered to be 500 mg/kg body weight.
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