4-nitrosophenol

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

experimental study

Adequacy of study:

key study

Study period:

6 hour - the publication describes this as a 'cell multiplication test'

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Only 6 hour exposure - the publication describes this as a 'cell multiplication test'
Data taken from a review of nitro-phenol substances
4-Nitrophenol considered suitable for read-across potential for toxicity the oxidation form of the nitrogen is not critical for short term toxic effects

Data source

Reference

Reference Type:

review article or handbook

Title:

Concise International Chemical Assessment Document 20

Author:

World Health Organisation

Year:

2000

Bibliographic source:

International Programme on Chemical Safety, Concise International Chemical Assessment Document 20

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Does not specify guideline. An exposure period of 6 hours is considered sufficient to estimate impact on cell division.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

4-nitrophenol

EC Number:

202-811-7

EC Name:

4-nitrophenol

Cas Number:

100-02-7

Molecular formula:

C6H5NO3

IUPAC Name:

4-Nitrophenol

Test material form:

solid: crystalline

Sampling and analysis

Analytical monitoring:

not specified

Test solutions

Vehicle:

not specified

Test organisms

Test organisms (species):

Chlorella vulgaris

Study design

Test type:

static

Water media type:

freshwater

Total exposure duration:

6 h

Remarks on exposure duration:

Short term test to estimate effect on cell division; considered good indicator of adverse effect

Test conditions

Hardness:

Not specified in the review document

Test temperature:

Not specified in the review document

pH:

Not specified in the review document

Dissolved oxygen:

Not specified in the review document

Results and discussion

Effect concentrations

Key result

Duration:

6 h

Dose descriptor:

EC50

Effect conc.:

ca. 6.97 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Details on results:

Described as 'cell multiplication inhibition test'

Applicant's summary and conclusion

Validity criteria fulfilled:

not specified

Conclusions:

Only 6 hour exposure - the publication describes this as a 'cell multiplication test'
Data taken from a review of nitro-phenol substances
4-Nitrophenol considered suitable for read-across potential for toxicity the oxidation form of the nitrogen is not critical for short term toxic effects
As data on two other tropic levels are provided, it is conisdered that further guideline testing is not required for Annex VII registration