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EC number: 819-688-6 | CAS number: 219828-90-7
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03 Oct 2011 - 26 Dec 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: Biodegradability of Chemical Substances by Microorganisms
- Version / remarks:
- Japanese notification, Yakushokuhatsu 0331 No. 8, Heisei 23.03.29 Seikyoku no. 5, KJanpokihatsu No.110331009, March 31, 2011
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Chemicals evaluation and research institute, japan
- Mixed liquor suspended solids (MLSS): 3300mg/L (BOD measurement), 3750 mg/L (recovery test) - Duration of test (contact time):
- ca. 28 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- TEST CONDITIONS
- pH: 5.5 - 6.9
- Temperature: 25±1°C
- Aeration of dilution water: not specified
- Suspended solids concentration: not specified
- Continuous darkness: (yes/no) not specified
TEST SYSTEM
- Culturing apparatus:
- Number of culture flasks/concentration: one activity control (aniline + activated sludge + basal medium), one inoculum blank (activated sludge + basal medium), three test suspensions (test substance + activated sludge + basal medium), one abiotic control (test substance + water)
- Measuring equipment: Closed system oxygen consumption measuring apparatus
- Test performed in closed vessels due to significant volatility of test substance: no
- Test performed in open system: no
SAMPLING
- Sampling frequency: continuously for 28 days - Reference substance:
- aniline
- Preliminary study:
- No preliminary study carried out
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- >= 15 - <= 16
- St. dev.:
- 0.577
- Sampling time:
- 28 d
- Parameter:
- % degradation (test mat. analysis)
- Value:
- > 99
- Sampling time:
- 28 d
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The test substance is not readily biodegradable. The test substance disappeared entirely and transformed into AMAA under the conditions of the study.
Reference
Description of key information
The average percentage of degradability based on biochemical oxygen demand (BOD) over the 28-day exposure period was 11%.
2-(Allyloxymethyl) acrylic acid methyl ester was concluded not to be readily biodegradable under the test conditions.
The average transformation rate of 2-(Allyloxymethyl) acrylic acid methyl ester to 2-(Allyloxymethyl) acrylic acid was 108%.
Key value for chemical safety assessment
Additional information
A ready biodegradability screening test was conducted (Mitsubishi Chemical Medience Corporation, 2011, Study A110354) to assess the potential for 2-(Allyloxymethyl) acrylic acid methyl ester to be degraded by microorganisms over a 28 -day period. The study was performed according to Japanese test guidelines and in compliance with GLP.
The average percentage of degradability based on biochemical oxygen demand (BOD) over the 28-day exposure period was 11%, so 2-(Allyloxymethyl) acrylic acid methyl ester was concluded not to be readily biodegradable under the test conditions. Despite low BOD (11%), the disappearance rates of the residual amount of the 2-(Allyloxymethyl) acrylic acid methyl ester were calculated to be 99% or greater. This suggests that the most of the 2-(Allyloxymethyl) acrylic acid methyl ester is transformed.
It has been reported that hydrolysis of the ester bond of the test item generates 2-(Allyloxymethyl) acrylic acid and methanol. According to the results of the quantitative determination of 2-(Allyloxymethyl) acrylic acid, the average transformation rate was 108%. Methanol is judged to be readily biodegradable and it was estimated to have been degraded by activated sludge.
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