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EC number: 217-793-6 | CAS number: 1955-46-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Short-term toxicity to aquatic invertebrates:
Based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted.
On the basis of this program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be267.218mg/l for test material in 48 hrs.
Based on this value it can be concluded that the substance is considered to be not toxic to aquatic environment and can not be classified as per the criteria mentioned in CLP regulation.
Toxicity to aquatic algae and cyanobacteria:
The short-term toxicity of the test substance to green algae is predicted using EPI Suite ECOSAR version 1.10. On the basis of effects observed in a static freshwater system during a 96 hr exposure, the effect concentration (EC50) for the substance is estimated to be166.185mg/L. Based on this value, it can be concluded that the test chemical can be considered as non-toxic to green algae at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria.
Additional information
Short-term toxicity to aquatic invertebrates:
The toxicity of test material was evaluated on aquatic invertebrate by considering prediction along with data for structurally similar read across substance.
The predicted studydone by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted.
On the basis of this program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be267.218mg/l for test material in 48 hrs.
Based on this value it can be concluded that the substance is considered to be not toxic to aquatic environment and can not be classified as per the criteria mentioned in CLP regulation.
The above prediction was further supported by data for structurally similar read across substance,study was conducted to determine the toxic effect of test chemical on the mobility of daphnia magna for 48hrs. Standards methods as per the OECD guideline were used in the test. 5 daphnids per concentration added in the test solution. Test performed in the 4 replicates, were observation of pH, effect on growth and other effects were measured.
Based on the immobility of daphnia magna for 48hrs of exposure duration with the chemical, the EC0 was 876 mg/l. Based on the effect of test chemical on the growth of daphnia magna, it can be concluded that the chemical was nontoxic and can be consider to be not classified as per the CLP classification criteria.
The above data was further supported by data for structurally similar read across substance, freshwater algal growth inhibition test was carried out on Desmodesmus subspicatus with the substance for total exposure period of 72 hrs. Test conducted according to OECD Guideline 201. The stock solution 100 mg/l was prepared by dissolving white powder in OECD growth medium. Test solutions of required concentration were prepared by mixing the stock solution of the test sample with OECD growth medium and inoculum culture and tested at the concentrations 0, 10, 18, 32, 58, 100 mg/L. Effects on the growth rate of the organism were studied by using positive reference substance Potassium dichromate (K2Cr2O7).
The median effective concentration (EC50) for Potassium dichromate in Desmodesmus subspicatus was determined to be 0.77 mg/L. The median effective concentration (EC50) for the test substance, in Desmodesmus subspicatus was determined to be 106.4 mg/L with 95% CI was 98.6 - 114.9 mg/l.
These values indicates that the test substance is likely to be non-hazardous to aquatic algae and cannot be classified as toxic and not classified as per the CLP criteria.
Toxicity to aquatic algae and cyanobacteria:
The toxicity of test material was evaluated on aquatic algae and cyanobaccteia by considering prediction along with data for structurally similar read across substance.
Based on the predictionusing EPI Suite ECOSAR version 1.10. On the basis of effects observed in a static freshwater system during a 96 hr exposure, the effect concentration (EC50) for the substance is estimated to be166.185mg/L. Based on this value, it can be concluded that the test chemical can be considered as non-toxic to green algae at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria.
The above prediction was supported by data for read across substancestudy was performed to evaluate the nature and effect of test chemical when it comes in contact with the aquatic algae Scenedesmus subspicatus. Test conducted according to the OECD guideline 201.
Based on the growth rate inhibition of Scenedesmus subspicatus (green algae) due to the test chemical the NOEC was 969 mg/l. As at 969 mg/ no effect were observed on the growth of algae so it can be consider that the concentration at which 50% growth inhibited was > 969 mg/l. hence on the basis of this phenomenon it can be concluded that the chemical was nontoxic and can be consider to be not classified as per the CLP classification criteria.
The above study was further supported by data for structutrally similar read across substance freshwater algal growth inhibition test was carried out on Desmodesmus subspicatus with the substance for total exposure period of 72 hrs. Test conducted according to OECD Guideline 201. The stock solution 100 mg/l was prepared by dissolving white powder in OECD growth medium. Test solutions of required concentration were prepared by mixing the stock solution of the test sample with OECD growth medium and inoculum culture and tested at the concentrations 0, 10, 18, 32, 58, 100 mg/L. Effects on the growth rate of the organism were studied by using positive reference substance Potassium dichromate (K2Cr2O7).
The median effective concentration (EC50) for Potassium dichromate in Desmodesmus subspicatus was determined to be 0.77 mg/L. The median effective concentration (EC50) for the test substance, in Desmodesmus subspicatus was determined to be 106.4 mg/L with 95% CI was 98.6 - 114.9 mg/l.
This value indicates that the substance test substance is likely to be non-hazardous to aquatic algae and cannot be classified as toxic and not classified as per the CLP criteria.
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