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EC number: 815-171-4 | CAS number: 300382-79-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-05-08 - 2018-11-12
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- United States Environmental Protection Agency, OPPTS 830.7840 - Water Solubility: Column Elution Method; Shake Flask Method, 1988.
- Deviations:
- yes
- Remarks:
- In the second attempt, all test solutions were stirred completely at 20 °C without previously being stirred at 30 °C.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- OECD - Organisation for Economic Co-operation and Development, OECD Guideline 105: Water Solubility, 1995
- Deviations:
- yes
- Remarks:
- In the second attempt, all test solutions were stirred completely at 20 °C without previously being stirred at 30 °C.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- N,N'-bis[2,4,6-tris(propan-2-yl)phenyl]methanediimine
- EC Number:
- 815-171-4
- Cas Number:
- 300382-79-0
- Molecular formula:
- C31H46N2
- IUPAC Name:
- N,N'-bis[2,4,6-tris(propan-2-yl)phenyl]methanediimine
- Test material form:
- liquid
- Remarks:
- yellow to brown
Constituent 1
Results and discussion
Water solubilityopen allclose all
- Water solubility:
- 2.3 µg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 93 mg/L
- Incubation duration:
- 48 h
- Temp.:
- 20 °C
- pH:
- 5
- Water solubility:
- < 1.7 µg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 94.5 mg/L
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- 5
- Remarks on result:
- other: It was determined to be below the LOQ of 1.7 μg/L
- Water solubility:
- < 1.7 µg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 92 mg/L
- Incubation duration:
- 96 h
- Temp.:
- 20 °C
- pH:
- 5
- Remarks on result:
- other: It was determined to be below the LOQ of 1.7 μg/L
Applicant's summary and conclusion
- Conclusions:
- The water solubility of the test item Bis(2,4,6-triisopropylphenyl)carbodiimide was determined according to OECD 105, using the flask method, under GLP with acceptable modifications, which may be considered as a scientifically reasonable approach. Hence, the observations and results can be considered reliable.
The water solubility of Bis(2,4,6-triisopropylphenyl)carbodiimide was determined to be 2.3 µg/L after 48 h shaking, and it was determined to be below the LOQ of 1.7 µg/L after 72 h resp. 96 h shaking. This fact and visualisation of the chromatograms indicate a time-dependent decrease in substance concentration. This first shows that the test item is practically insoluble in water, and second, that it is not stable over time in water. - Executive summary:
The water solubility of the test item Bis(2,4,6-triisopropylphenyl)carbodiimide in demineralized water was determined with the shake flask method at 20 °C according to OECD 105 and OPPTS 830.7840 under GLP. According to the results of a preliminary test the column elution method should be carried out but the test item is a liquid and therefore the flask method was applied.
The concentration of the test item in the aqueous test solutions was determined by HPLC analysis with MS detection.
In a first attempt the results showed a large deviation. Therefore a second attempt with deviations from OECD 105 was carried out. All test solutions were stirred completely at 20 °C without previously being stirred at 30 °C.
Table Results of individual determinations and mean value
Water solubility test at 20 °C
Flask A [µg/L]
Flask B [µg/L]
Flask C [µg/L]
Stirring time (at 20 °C)
96 h
72 h
48 h
Concentration of Bis(2,4,6-triisopropylphenyl)carbodiimide
< 1.7
< 1.7
2.3
pH-value
5
5
5
Water solubility of Bis(2,4,6-triisopropylphenyl)carbodiimide at 20 °C after shaking for 48 hours: 2.3 µg/L
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