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EC number: 441-070-6 | CAS number: 61826-76-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 441-070-6
- EC Name:
- -
- Cas Number:
- 61826-76-4
- Molecular formula:
- C14H11NO2
- IUPAC Name:
- (2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Samples of test media for determination of the actual concentrations of the test item and the degradation product were taken before settin-in of the fish and after ca. 4 and 96 hours.
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- < 250 mg CaCO3/L
- Nominal and measured concentrations:
- Nominal concentrations: 0, 0.5, 0.9, 1.6, 2.8 and 5.0 mg/L
- Details on test conditions:
- 7 fish each were exposed to five concentrations of the test substance (0.5, 0.9, 1.6, 2.8 and 5.0 mg/L) in dilution water, obtained by mixing local tap water with deionized water to achieve the appropriate water hardness as required by the guideline. Additionally, 7 fish were used for one control group. The following investigations were conducted during the study:
- mortality, observations in life
- total hardness of the control water
- pH in the control and test medium at the start and at 24,48,72 and 96 hours
- temperature in the control and test medium at the start and after ca. 24, 48, 72 and 96 hours.
- dissolved oxygen concentration in the control and test media at the start and after ca. 24, 48, 72 and 96 hours
- the test substance was determined at the start and after 4 hours and the degradation product was determined at the start and after 4 and 96 hours
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 72 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 2.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 0.9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- Temperature was stable through the test period. Dissolved oxygen concentration was always higher than 84% of the air saturation value at the appropriate temperature. The pH value of the test substance solution did not change more than one unit within the test period.
Any other information on results incl. tables
- Sublethal observations / clinical signs:
Analytical measurements:
The test substance hydrolyses rapidly. After 4 hours the test substance concentration was already below the detection limit of 0.2 mg/L. The concentrations of the hydrolysis product were also determined and were stable between 4 hours after begin of the exposure and the end of the test.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- A static acute toxicity test with Danio rerio, applying a nominal concentration of up to 5.0 mg/L test item was conducted according to EU method C.1. The following lethal concentrations were determined after treatment with the test item:
- 96 h LC50: 1.4 mg/L (95% confidence limit (upper 1.7, lower 1.1)
- 96 h LC0: 0.9 mg/L. - Executive summary:
A static acute toxicity test with Danio rerio, applying a nominal concentration of up to 5.0 mg/L test item, was conducted according to EU method C.1. The following lethal concentrations were determined after treatment with the test item:
- 96 h LC50: 1.4 mg/L (95% confidence limit (upper 1.7, lower 1.1)
- 96 h LC0: 0.9 mg/L.
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