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Diss Factsheets
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EC number: 220-482-8 | CAS number: 2781-11-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity, other
- Remarks:
- acute oral and intraperitoneal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test: Assessment of physiological neurotoxicity signs after administration of test substance
- Short description of test conditions: test substance was administered once orally or intraperitoneally and the animals were observed for 28 d.
- Parameters observed: neurotoxic symptoms such as ataxy or paralysis - GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Diethyl bis(2-hydroxyethyl)aminomethylphosphonate
- EC Number:
- 220-482-8
- EC Name:
- Diethyl bis(2-hydroxyethyl)aminomethylphosphonate
- Cas Number:
- 2781-11-5
- Molecular formula:
- C9H22NO5P
- IUPAC Name:
- diethyl {[bis(2-hydroxyethyl)amino]methyl}phosphonate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- hen
- Strain:
- other: Leghorn (white)
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Breeder Gierlich, Bochum, Germany
Administration / exposure
- Route of administration:
- other: oral and intraperitioneal
- Vehicle:
- water
- Remarks:
- destilled
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- After a single treatment, animals were observed for 28 days.
- Frequency of treatment:
- Once
Doses / concentrationsopen allclose all
- Dose / conc.:
- 500 mg/kg bw/day
- Remarks:
- oral
- Dose / conc.:
- 1 000 mg/kg bw/day
- Remarks:
- oral
- Dose / conc.:
- 2 500 mg/kg bw/day
- Remarks:
- oral and intraperitoneal
- Dose / conc.:
- 3 750 mg/kg bw/day
- Remarks:
- intraperitoneal
- Dose / conc.:
- 5 000 mg/kg bw/day
- Remarks:
- oral and intraperitoneal
- No. of animals per sex per dose:
- one animal/dose (for 500, 1000 and 2500 mg/kg bw);
5 animals/dose (for 5000 mg/kg bw) - Control animals:
- no
Examinations
- Observations and clinical examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: Yes
- Effects observed: neurotoxic symptoms (e.g. ataxia, paralysis)
DETAILED CLINICAL OBSERVATIONS: No
BODY WEIGHT: No
WATER CONSUMPTION AND COMPOUND INTAKE: No data
OPHTHALMOSCOPIC EXAMINATION: No - Specific biochemical examinations:
- NEUROPATHY TARGET ESTERASE (NTE) ACTIVITY: No
CHOLINESTERASE ACTIVITY: No - Neurobehavioural examinations performed and frequency:
- FUNCTIONAL OBSERVATIONAL BATTERY: No
LOCOMOTOR ACTIVITY: No
AUDITORY STARTLE REFLEX HABITUATION: No
LEARNING AND MEMORY TESTING: No
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Body weight and weight changes:
- not examined
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not examined
- Immunological findings:
- not examined
- Organ weight findings including organ / body weight ratios:
- not examined
- Gross pathological findings:
- not examined
- Neuropathological findings:
- not examined
- Histopathological findings: non-neoplastic:
- not examined
- Histopathological findings: neoplastic:
- not examined
Effect levels
- Key result
- Dose descriptor:
- dose level:
- Effect level:
- > 5 000 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- behaviour (functional findings)
Applicant's summary and conclusion
- Executive summary:
No neurotoxic symthomes were reported in this early acute delayed neurotoxicity study in chickens.
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