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EC number: 257-048-2 | CAS number: 51200-87-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test:
Acute Inhalation Toxicity of P-1585 (Oxazolodine-A) in male albino rats
- Short description of test conditions: The Acute Inhalation Toxicity of P-1585 was measured through exposure of the test substance as a mist for one hour. The rats were observed during the exposure duration and a period of 14 days. The rats were then necropsied.
- Parameters analysed / observed: pharmacodynamic and toxic signs during and after exposure period for 14 days; gross necropsy after 14 days or if the animal died during the observation period - GLP compliance:
- not specified
- Test type:
- traditional method
- Limit test:
- no
Test material
- Reference substance name:
- 4,4-dimethyloxazolidine
- EC Number:
- 257-048-2
- EC Name:
- 4,4-dimethyloxazolidine
- Cas Number:
- 51200-87-4
- Molecular formula:
- C5H11NO
- IUPAC Name:
- 4,4-dimethyl-1,3-oxazolidine
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name: P-1585 / Oxazolidine A 87.4%
- Source and lot/batch No.of test material: Commercial Solvents Corporation, Terre Haute, Indiana, lot 575916JH
- Purity: 87.4%
Test animals
- Species:
- rat
- Strain:
- other:
- Remarks:
- Spartan Strain
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 205 to 250 g
- Housing: metal cages
- Diet: Purina Laboratory Chew ad libitum
- Water: ad libitum
Temperature and humudity controlled quarters.
Administration / exposure
- Route of administration:
- inhalation: mist
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: sealed glass chamber
- Exposure chamber volume: 59.1 l
- Method of holding animals in test chamber: none, rats were separted into 4 units of 2 or 3 rats each
- Rate of air: 0.382 ml/min
- Method: Controlled by a Harvard Dual Infusion/Withdrawal Pump with a 50 cc syringe. Dried and filterted air was passed through the mechanism and directly into the exposure chamber. Airflow was regulated by means a flowmeter.
- Temperature, humidity, pressure in air chamber: not specified
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 1 h
- Concentrations:
- Calculated atmospheric concentrations: 3.125, 6.5, 12.5, 25 and 50 mg/l
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not specified
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 11.66 mg/L air
- Based on:
- test mat.
- 95% CL:
- >= 9.3 - <= 14.63
- Exp. duration:
- 1 h
- Mortality:
- None of the rats at atmospheric concentrations of 3.125 and 6.25 mg/l died during the exposure and the subsequent 14 day observation period.
Six of 10 rats at the 12.5 mg/l level died within 2 days of the observation period.
All rats receiving the test compound at concentrations of 25 and 50 mg/l died within 3 days after the exposure period. - Clinical signs:
- other: Signs seen during the exposure period: 3.125 mg/l nasal discharge, eye squint, marked dyspnea (gasping), salivation, lacrimation, erythema, decreased respiratory rates and decreased motor activity. 6.25 mg/l: additionally ocular and nasal porphyrin disc
- Body weight:
- All surviving rats at the 3.125 and 6.25 mg/l exposures exhibited normal body weight gains. Rats surviving the 12.5 mg/l concentration exhibited body weight gains, however, the gains noted were considered less then the normal gains exhibited by untreated rats of this age and strain in this laboratory.
- Gross pathology:
- In rats dying at 25 & 50 mg/kg necropsy findings in most rats included bloody nasal discharge, moderate to severe lung hemorrhage, mode to severe congestion of the liver and corneal opacity and thickening (probalby edema). At 12.5 mg/kg findings in most rats were limited to liver and lung congestion. One rat at this level had hemorrhage with bloddy nasal discharge.
Any other information on results incl. tables
3.125 mg/l:
Signs seen during the exposure period included nasal discharge, eye squint, marked dyspnea (gasping), salivation, lacrimation, erythema, decreased respiratory rates and decreased motor activity. At 24 hours all rats were normal with the exception that corneal opacity, sweling of the conjunctival tissue and corneals lesions were observed. These signs of ocular irritation were noted throughout the 14 day observation period.
6.25 mg/l:
Signs seen during the exposure period were essentially those observed above at the 3.125 mg/l concentration. In addition ocular and nasal porphyrin discharge were observed. At 24 hours nasal discharge, gasping and nasal porphyrin discharge were observed as were corneal opacity and respiratory congestion. At 6 days corneal opacity and swelling of the conjunctival tissues was observed. These signs of ocular irritation continued in evidence for the duration of the observation period.
12.5 mg/l:
In addition to these signs noted above, ataxia was also observed at this concentration during the exposure. At 24 hours nasal discharge, prostration, nasal porphyrin discharge, blanching, decreased respiratory rates, ataxia and decreased motor activity were noted as was intermittent body jerking and respiratory congestion. One rat was found dead at 24 hours. At 48 hours dyspnea, decreased respiratory rates, respiratory congestion, corneal opacity, blanching and bloated abdomen were noted. Five rats were found dead at 48 hours. From 3 to 9 days respiratory congestion, and corneal opacity remained in evidence and during the 3rd, 4th and 5th days blanching was also observed. From the 10th to 14th day respiratory congestion and corneal opacity, continued in evidence. Also observed at this time was corneal balging, lesions on the corneal surface and swelling of the conjunctial tissue.
25 and 50 mg/l:
Signs noted at each of these levels during the exposure period were essentially similar to those observed at the 12.5 mg/l concentration. In addition, blood and foam emitted from the nose, intermittent body jerking, respiratory congestion and blanching were observed at both atmospheric concentrations. At 24 hours signs observed at each of these levels included marked dyspnea (gasping), nasal porphyrin discharge, blanching, decreased respiratory rates, ataxis, decreased motor activity, respiratory congestion, myasthenia and corneal opacity. In addition nasal discharge, foam emitted from the nose and ocular porphyrin discharge also were observed at the 50 mg/l concentration. Three rats were found dead at the 25 mg/l concentration and 2 at the 50 mg/ l concentration at 24 hours. At 48 hours, 6 rats were dead at the 25 mg/l concentration and 7 ras at the 50 mg/ l level. The one surviving rat in each group exhibited signs similar to those noted at 24 hours. The surviving rat in each group was found dead at 3 days.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Based upon the results obtained, the acute inhalation toxicity (LC50) of P-1585 Oxazolidine- A, in the male albino rat after 1h exposure was found to be 11.66 mg/l with confidence limits from 9.3 to 14.63 mg/l.
The calculated LC50 for male rat exposed during 4 h is 11.6 mg/l /4= 2.91 mg/l. - Executive summary:
Based upon the results obtained, the acute inhalation toxicity (LC50) of P-1585 Oxazolidine- A, in the male albino rat after 1h exposure was found to be 11.66 mg/l with confidence limits from 9.3 to 14.63 mg/l.
The calculated LC50 for male rat exposed during 4 h is 11.6 mg/l /4= 2.91 mg/l.
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