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EC number: 243-077-8 | CAS number: 19455-20-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08 Jan 2020 - 24 Jan 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- Potassium isobutyrate
- EC Number:
- 243-077-8
- EC Name:
- Potassium isobutyrate
- Cas Number:
- 19455-20-0
- Molecular formula:
- C4H8O2.K
- IUPAC Name:
- potassium 2-methylpropanoate
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch number of test material: Sponsor / 181101001
- Expiration date of the lot/batch: 31 Oct 2020
- Purity test date: 09 Nov 2018
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room Temperature (20 ± 5 °C); keep away from humidity; keep under inert gas
- Stability under storage conditions: stable
Results and discussion
Water solubility
- Key result
- Water solubility:
- >= 945.02 - <= 990.96 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 11
- Details on results:
- Flasks 1A-C were used for determination of the equilibration phase only. The water solu-bility of the test item was determined from flasks 2 – 4 at 20.0 ± 0.5 °C and a pH value of 11 as 967.99 ± 22.97 g/L, corresponding to a relative standard deviation of 2.4 %.
Any other information on results incl. tables
The following table gives an overview on the determined solubility of the test item in demineralised water.
Table 4. Determined Solubility in Demineralised Water
Flask |
Temperature [°C] |
pH |
Nominal Concentration [g/L] |
Measured Concentration [g/L] |
1A |
20.0 |
11 |
3000.9 |
1012.34 |
1B |
19.9 |
11 |
3001.8 |
974.70 |
1C |
19.8 |
11 |
3002.8 |
880.37 |
2 |
19.8 |
11 |
2999.3 |
992.66 |
3 |
20.1 |
11 |
3000.2 |
964.10 |
4 |
19.9 |
11 |
3003.5 |
947.22 |
Applicant's summary and conclusion
- Conclusions:
- At the plateau, the concentration of Potassium isobutyrate in water had reached:
967.99 ± 22.97 g/L at 20.0 ± 0.5 °C and a pH value of 11
= 967.99 ± 22.97 kg/m3 (SI units)
(mean value ± standard deviation of three individual vessels) - Executive summary:
Findings and Results:
The solubility of the test item Potassium isobutyrate in water using the flask method was determined using a validated method for HPLC-UV measurements.
For determination of the solubility of the test item, the preliminary test described in the guideline was performed and to 103 mg of the test item, water was added stepwise. Al-ready after addition of 0.1 mL of water, the test item was completely dissolved. Thus, the solubility was estimated to be higher than 1000 g/L. Additional preliminary tests were per-formed to find the concentration where the test was is completely moistened and a filterable mixture was formed. The highest nominal concentration fulfilling these criteria was 3000 g/L. The solution was filtered using PTFE membrane filters (0.45 µm) and measured using HPLC-UV. The solubility of the test item was estimated as 973.71 g/L. As the solubility of the test item was very high, the nominal concentration of 3000 g/L was chosen for the main test since at this concentration, the test item was completely moistened and the solution was still filterable.
Five vessels (flasks 1C (for the sampling point 72 h) and flasks 2 – 4, blank sample) were set onto the shaking apparatus immediately and shaking was started. After 24 ± 2 h, flask 1B (for the sampling point 48 h) and after 48 ± 2 h, flask 1A (for the sampling point 24 h) were set on the shaker and all flasks were shaken for further 24 ± 2 h at room temperature. Then, flasks 1A-C were taken from the shaker and tempered at 20.0 ± 0.5 °C. Aliquots were taken, membrane filtrated (0.45 µm, PTFE) and diluted to reach the calibrated range.
Because of a difference of less than 15 % in the concentrations on days 2 and 3 and no upward tendency in the three values, the test was finished on day 3.
The final measurement was performed as determination from flasks 2 – 4. None of the filtrated test solutions showed a Tyndall effect (i.e. a laser beam was not scattered when transmitted through the liquid).
At the plateau, the concentration of Potassium isobutyrate in water had reached
967.99 ± 22.97 g/L at 20.0 ± 0.5 °C and a pH value of 11
= 967.99 ± 22.97 kg/m3 (SI units)
(mean value ± standard deviation of three individual vessels)
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