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EC number: 219-919-5 | CAS number: 2571-88-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
- were not irritating to the skin and eye at low concentrations (1%),
- were moderately irritating at 5%,
- more severely irritating when tested as produced (e.g., ~30% aqueous solutions).
- and there is no need to test the pure compound for irritation since it is not available in that form and the consumer will never be exposed to this concentration.
- .5%, is not irritating to the skin.
- one for eye irritation : the substance at a concentration of 2.5% is not irritating to the skin.
Different studies (SIDS, 2006) indicate that Amine Oxides:
Concerning the N,N-Dimethyl-1-octadecanamine-N-oxide, two studies are available:
one for skin irritation : the substance at a concentration of 2
In conclusion, the behaviour of the substance is in the scope of Amine Oxide category and the global conclusion of the SIDS report can be used.
N,N-Dimethyl-1-octadecanamine-N-oxide (CAS 2571-88-2 / EINECS 219-919-5) is considered as Skin Irritant H315 and Eye Irritant H319.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- Draize method
- Principles of method if other than guideline:
- Four skin lotions, containing 2.5% C18 Amine Oxide (CAS No. 2571-88-2), were tested for skin irritation in rabbits according to the Draize method. The objective is to compare the skin irritation score between skin lotion containing mineral oil or isopropyl palmitate.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- other: skin lotion
- Controls:
- not specified
- Amount / concentration applied:
- 2.5%
- Duration of treatment / exposure:
- 72 hours
- Observation period:
- 14 days
- Number of animals:
- 1-3
- Irritation parameter:
- primary dermal irritation index (PDII)
- Remarks:
- Lotion 1 (mineral oil, no quat)
- Basis:
- mean
- Time point:
- 72 h
- Score:
- ca. 4
- Reversibility:
- not specified
- Remarks on result:
- other: 2.5% C18 Amine Oxide did not impact the irritation profile of these skin lotions
- Irritation parameter:
- primary dermal irritation index (PDII)
- Remarks:
- Lotion 2 (mineral oil, quat)
- Basis:
- mean
- Time point:
- 72 h
- Score:
- ca. 6
- Reversibility:
- not specified
- Remarks on result:
- other: 2.5% C18 Amine Oxide did not impact the irritation profile of these skin lotions
- Irritation parameter:
- primary dermal irritation index (PDII)
- Remarks:
- Lotion 3 (isopropyl palmitate, no quat)
- Basis:
- mean
- Time point:
- 72 h
- Score:
- ca. 0
- Reversibility:
- not specified
- Remarks on result:
- other: 2.5% C18 Amine Oxide did not impact the irritation profile of these skin lotions
- Irritation parameter:
- primary dermal irritation index (PDII)
- Remarks:
- Lotion 4 (isopropyl palmitate, quat)
- Basis:
- mean
- Time point:
- 72 h
- Score:
- ca. 0
- Reversibility:
- not specified
- Remarks on result:
- other: 2.5% C18 Amine Oxide did not impact the irritation profile of these skin lotions
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritant / corrosive response data:
- 2.5% C18 Amine Oxide did not impact the irritation profile of these skin lotions
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- N,N-Dimethyl-1-octadecanamine-N-oxide (CAS 2571-88-2 / EINECS 219-919-5) was evaluated for primary skin irritation in rabbits. The authors demonstrated the minimal to moderate skin irritation observed with two of the four formulas was due to the presence of 35% mineral oil with a single variable substitution with 35% isopropyl palmitate. All of the skin lotions contained 2.5% C18 AO, only those with mineral oil were skin irritants.
- Executive summary:
- N,N-Dimethyl-1-octadecanamine-N-oxide (CAS 2571-88-2 / EINECS 219-919-5) was evaluated for primary skin irritation in rabbits. The authors demonstrated the minimal to moderate skin irritation observed with two of the four formulas was due to the presence of 35% mineral oil with a single variable substitution with 35% isopropyl palmitate. All of the skin lotions contained 2.5% C18 AO, only those with mineral oil were skin irritants.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Vehicle:
- other: skin lotion
- Controls:
- not specified
- Amount / concentration applied:
- Not specified
- Duration of treatment / exposure:
- Not specified
- Observation period (in vivo):
- Not specified
- Number of animals or in vitro replicates:
- 1-3
- Details on study design:
- For rabbits with washed eye treatment, washing occurred 4 seconds after application
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritant / corrosive response data:
- No irritation was observed in rabbits with washed or unwashed eyes
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- N,N-Dimethyl-1-octadecanamine-N-oxide (CAS 2571-88-2 / EINECS 219-919-5) was evaluated for eye irritation in the rabbit according to the Draize method. Four skin lotions containing 2.5% C18 Amine Oxide were tested and shown to be non irritating.
- Executive summary:
N,N-Dimethyl-1-octadecanamine-N-oxide (CAS 2571-88-2 / EINECS 219-919-5) was evaluated for eye irritation in the rabbit according to the Draize method. Four skin lotions containing 2.5% C18 Amine Oxide were tested and shown to be non irritating.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
As indicated in the read-across justification, data from Amine oxide can be used for read-across to N,N-Dimethyl-1-octadecanamine-N-oxide (CAS 2571-88-2 / EINECS 219-919-5).
For skin and eye irritation, two studies on N,N-Dimethyl-1-octadecanamine-N-oxide has been used with a read-across justification in supporting study.
N,N-Dimethyl-1-octadecanamine-N-oxide is considered as Skin and Eye Irritant, H315, H319.
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