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Diss Factsheets
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EC number: 700-636-5 | CAS number: 5413-49-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LD50 (oral) > 5000 mg/kg bw
LD50 (dermal) > 2000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
The acute toxic effects of the substance via the oral and dermal route were evaluated by the use of an analogous substance, due to the absence of available data on the substance itself. Justification for Read Across is given in Section 13 of IUCLID.
Acute oral toxicity
The toxicity of the test material to rats after their single, acute dermal exposure to the substance was evaluated in a limit test according to the OECD Guideline 425 and EPA OPPTS 870.1100 and n compliance with GLP. Initially, one healthy female Sprague Dawley rat was dosed orally at 5000 mg/kg bw. Since the animal survived, four additional animals were dosed at 5000 mg/kg bw. The animals were observed for 14 days for mortality and clinical signs, body weight changes and the survivors were necropsied. Three out of five female rats survived the single 5000 mg/kg bw oral dose. LD50 > 5000 mg/kg bw.
Acute dermal toxicity
The toxicity of the test material to rats after their single, acute dermal exposure to the substance was evaluated in a limit test according to the OECD Guideline 402 and EU Method B.3 and in compliance with GLP. Five male and five female Wistar rats were dermally exposed to a single dose of the substance at 2000 mg/kg bw. The test substance was held in contact with the skin with a semi-occlusive dressing which was removed after 24 hours of exposure. The animals were observed for 15 days for mortality, clinical signs, body weight changes and necropsy were conducted after the end of the study. No mortality was observed. Chromodacryorrhoea of the snout was noted for one male and two females on Day 1 while pelvic dilation of the kidney was noted for a single male. This necropsy finding is commonly noted among rats of this age and strain and was therefore considered not toxicologically significant. LD50 > 2000 mg/kg bw
Justification for classification or non-classification
For the evaluation of the classification of the substance the lethal doses (LD50) from both oral and dermal acute toxicity studies are considered.
Both LD50s are higher than the threshold for classification (i.e. LD50>2000 mg/kg bw), as indicated in the CLP Regulation (EC) No. 1272/2008 and therefore the substance is not classified for acute toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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