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EC number: 284-294-8 | CAS number: 84837-14-9 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Thymus mastichina, Labiatae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- other: bibliography
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data is cited in the database as peer reviewed.
No study was conducted on the oil iself, as not relevant for an UVCB. Literature provided data for the 8 major components representing 84.7%. - Qualifier:
- according to guideline
- Guideline:
- other: [Yalkowsky, S.H., He, Yan, Jain, P. Handbook of Aqueous Solubility Data Second Edition. CRC Press, Boca Raton, FL 2010, p. 730] **PEER REVIEWED**
- Water solubility:
- 3 500 mg/L
- Temp.:
- 21 °C
- pH:
- 7
- Remarks on result:
- other: no data on pH
- Conclusions:
- Water solubility of cineol is 3500 mg/L at 21°C.
- Endpoint:
- water solubility
- Type of information:
- other: bibliography
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data is cited in the database as peer reviewed.
No study was conducted on the oil iself, as not relevant for an UVCB. Literature provided data for the 8 major components representing 84.7%. - Qualifier:
- according to guideline
- Guideline:
- other: [Massaldi HA, King CJ; J Chem Eng Data 18: 393-7 (1973)] **PEER REVIEWED**
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Water solubility:
- 13.8 mg/L
- Temp.:
- 25 °C
- pH:
- 7
- Remarks on result:
- other: no data on pH
- Conclusions:
- Water solubility of limonene is 13.8 mg/L at 25°C.
- Endpoint:
- water solubility
- Type of information:
- other: bibliography
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data is cited in the database as peer reviewed.
No study was conducted on the oil iself, as not relevant for an UVCB. Literature provided data for the 8 major components representing 84.7%. - Qualifier:
- according to guideline
- Guideline:
- other: [SRI Consulting. 2011 Directory of Chemical Producers United States. SRI Consulting, Menlo Park, CA 2011, p. 728] **PEER REVIEWED**
- GLP compliance:
- not specified
- Water solubility:
- 1 590 mg/L
- Temp.:
- 25 °C
- pH:
- 7
- Remarks on result:
- other: no data on pH
- Conclusions:
- Water solubility of linalol is 1590 mg/L at 25°C.
- Endpoint:
- water solubility
- Type of information:
- other: bibliography
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data is cited in the database as peer reviewed.
No study was conducted on the oil iself, as not relevant for an UVCB. Literature provided data for the 8 major components representing 84.7%. - Qualifier:
- according to guideline
- Guideline:
- other: [Yalkowsky, S.H., He, Yan, Jain, P. Handbook of Aqueous Solubility Data Second Edition. CRC Press, Boca Raton, FL 2010, p. 714] **PEER REVIEWED**
- Qualifier:
- according to guideline
- Guideline:
- other: [Chemicals Inspection and Testing Institute; Biodegradation and bioaccumulation data of existing chemicals based on the CSCL Japan. Japan Chemical Industry Ecology - Toxicology and Information Center. ISBN 4-89074-101-1 (1992)] **PEER REVIEWED**
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Water solubility:
- > 4.09 - < 5.6 mg/L
- Temp.:
- 25 °C
- pH:
- 7
- Remarks on result:
- other: no data on pH
- Conclusions:
- Water solubility of myrcene is between 4.09 and 5.60 mg/L at 25°C.
- Endpoint:
- water solubility
- Type of information:
- other: bibliography
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data is cited in the database as peer reviewed.
No study was conducted on the oil iself, as not relevant for an UVCB. Literature provided data for the 8 major components representing 84.7%. - Qualifier:
- according to guideline
- Guideline:
- other: [Li J, Perdue EM; Physicochemical Properties of Selected Monoterpenes. Pre-print Extended Abstract, Presented Before The Division of Environmental Chemistry, Amer Chem Soc, Anaheim, Ca: April 2-7 (1995)] **PEER REVIEWED**
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Water solubility:
- 2.49 mg/L
- Temp.:
- 25 °C
- pH:
- ca. 7
- Remarks on result:
- other: no data on pH
- Conclusions:
- Water solubility of Pinene alpha is 2.49 mg/L at 25°C.
- Endpoint:
- water solubility
- Type of information:
- other: bibliography
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data is cited in the database as peer reviewed.
No study was conducted on the oil iself, as not relevant for an UVCB. Literature provided data for the 8 major components representing 84.7%. - Qualifier:
- according to guideline
- Guideline:
- other: [US EPA; Estimation Program Interface (EPI) Suite. Ver.3.12. Nov 30, 2004. Available from, as of Sept 24, 2008: http://www.epa.gov/oppt/exposure/pubs/episuitedl.htm] **PEER REVIEWED**
- Version / remarks:
- v3.12
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Water solubility:
- 4.89 mg/L
- Temp.:
- 25 °C
- pH:
- ca. 7
- Remarks on result:
- other: no data on pH.
- Conclusions:
- Water solubility of Pinene beta is 4.89 mg/L at 25°C.
- Endpoint:
- water solubility
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- There is no experimental study reference. EPI suite software accepted by ECHA
No study was conducted on the oil iself, as not relevant for an UVCB. Literature provided data for the 8 major components representing 84.7%. - Qualifier:
- according to guideline
- Guideline:
- other: EPI suite v4.11
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Water solubility:
- 2.494 mg/L
- Temp.:
- 25 °C
- pH:
- 7
- Remarks on result:
- other: no data on pH
- Conclusions:
- Water solubility of sabinene is 2.494 mg/L at 25°C.
- Endpoint:
- water solubility
- Type of information:
- other: bibliography
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data is cited in the database as peer reviewed.
No study was conducted on the oil iself, as not relevant for an UVCB. Literature provided data for the 8 major components representing 84.7%. - Qualifier:
- according to guideline
- Guideline:
- other: [Li J, Perdue EM; Preprints of Papers Presented at the 209th ACS National Meeting, Anaheim, CA, April 2-7, 1995, 35: 134-7 (1995)] **PEER REVIEWED**
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Water solubility:
- 7 100 mg/L
- Temp.:
- 25 °C
- pH:
- 7
- Remarks on result:
- other: no data on pH
- Conclusions:
- Water solubility of terpineol alpha is 7100 mg/L at 25°C.
Referenceopen allclose all
Description of key information
No study was conducted on the essential oil iself, as not relevant for an UVCB.
The test item is a natural complex substance (NCS). It is a mixture of several constituents, but eight of them represent more than 84.7% of that mixture.
Literature and QSAR provided data for these 8 major components ranging between 2.49 mg/L and 7100 mg/L with details below :
Constituent names | CAS nr | water solubility at 25°C | source |
pinene alpha | 80 -56 -8 | 2.49 mg/L | HSDB |
pinene beta | 127 -91 -3 | 4.89 mg/L | HSDB |
sabinene | 3387-41-5 | 2.49 mg/L | EPI suite v4.11 |
myrcene | 123 -35 -3 | 4.09 to 5.6 mg/L | HSDB |
limonene | 5989-27-5 | 13.8 mg/L | HSDB |
cineol | 470-82-6 | 3500 mg/L | HSDB |
linalol | 78 -70 -6 | 1590 mg/L |
HSDB |
terpineol alpha | 98-55-5 | 7100 mg/L | HSDB |
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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