Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 424-650-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Vehicle:
- no
- Details on test solutions:
- A saturated solution of Donor C20 was prepared by mechanical stirring for 20 hours followed by 4h standing.
- Test organisms (species):
- Daphnia magna
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 20°C
- Nominal and measured concentrations:
- Donor C20 was tested at its aqueous solubility and at its 10, 18, 32, and 56 volume percent dilutions.
The acutal concentration of Donor C20 was determined by chemical analysis - Details on test conditions:
- The test was carried out under 16h light/8h dark regime. The test was performed in 150 ml all-glass beakers, each containing 100 ml of control or test medium. Four beakers containing 5 daphnids each were used for the control or test medium.
The control and test media were not aerated or replaced. The daphnids were not fed. The pH and oxygen concentration were measured at the beginning and at the end of the test.
The test vessels were checked for mobility of the test animals after 24 hours and at the end of the test. At the same time the condition of the mobile animals was compared with that of control animals. - Reference substance (positive control):
- not specified
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- >= 7.9 mg/L
- Nominal / measured:
- estimated
- Basis for effect:
- mobility
- Remarks on result:
- other: Above the limit of aqueous solubility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 7.9 mg/L
- Nominal / measured:
- meas. (not specified)
- Basis for effect:
- mobility
- Remarks on result:
- other: Limit of aqueous solubility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 4.42 mg/L
- Nominal / measured:
- meas. (not specified)
- Basis for effect:
- behaviour
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 7.9 mg/L
- Nominal / measured:
- meas. (not specified)
- Basis for effect:
- behaviour
- Details on results:
- An effect was observed at the highest dose tested with the animals showing a slow and disturbed swimming behaviour. This led to setting the LOEC at the highest dose tested (100% aqueous solubility)
- Validity criteria fulfilled:
- yes
- Conclusions:
- With respect to mobility, Donor C20 is not acutely toxic to Daphnia magna. With regards to the condition observed at the highest achievable water saturation, slow and disturbed swimming, establishing that dose (7.9 mg/l) as the LOEC with the NOEC at 56% of the maximum solubility or 4.42 mg/l.
Reference
Description of key information
In a GLP-compliant, OECD guideline study, changes in swimming behaviour were observed at the highest concentration tested, however, no effects on mobility was observed at the limit of aqueous solubility (7.9 mg/l).
Key value for chemical safety assessment
Additional information
It is not appropriate to include an EC50 value for the chemical safety assessment above as this is determined to be greater than the limit of aqueous solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.