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Diss Factsheets
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EC number: 915-932-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 9 May 1990 - 23 May1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction mass of dipotassium 3,3'-sulphonylbis(benzenesulphonate) and potassium 3-(phenylsulphonyl)benzenesulphonate
- EC Number:
- 915-932-1
- Molecular formula:
- Reaction mass of C12H8O8S3.2K and C12H9O5S2.K
- IUPAC Name:
- Reaction mass of dipotassium 3,3'-sulphonylbis(benzenesulphonate) and potassium 3-(phenylsulphonyl)benzenesulphonate
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- Test substance: Additive VP KU 1-1909
Lot#: DZA-UER -8919598-A
Manufacturer: Bayer AG, Leverkusen
Purity: 86.5% (see annex, appendix.3)
Identity/Stability: guaranteed for the study period
Storage: room temp, darkness
CAS #: 63316-43-8
Molecular weight: 336 g/mol
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The rats were housed in cages on low dust wood granules, at a room temperature of 22 +/- 2 degrees celsius, with artificial lighting from 6am to 6 pm, relitive humidity of about 50 +/- 10% and aprox ten air changes per hour. All animals used for this experiment were house in a single room. At the samw time animals from other acute studies were kept in the same animal room. Due to sufficient spatial separation the adequate organization of the sequence of operations a mixing up of animals of influence by another was excluded.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- The substance was dissolved in tap water on a magnetic stirrer at approx. 60 degrees celsius and then applied to the prepared skin area at a volume corresponding to dose and animal weight. it was covered with gauze and aluminum foil and fixed with non-irritant skin plaster. The dressing was removed after approx 24 hours and possible substance residues on the skin were removed with luke-warm water.
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg-bw
- No. of animals per sex per dose:
- 5 males and 5 females, each given 2000 mg/kg-bw.
- Control animals:
- no
- Details on study design:
- The animals were inspected several times on the day of administration and twice daily during the following 14-day observation period for clinical signs. Animals were individually weighed directly before administration and then once a week until the end of the observation period. Gross pathological examinations were done on all animals.
- Statistics:
- None. No animals died during the exposure or 14 day observation period.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- >= 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 0%. No animals died during the exposure or 14 day observation period.
- Clinical signs:
- other: No clinical signs were observed.
- Gross pathology:
- No noticeable gross pathological findings
Any other information on results incl. tables
No clinical signs, changes in body weight, mortality, or gross pathological findings were noted in any of the 10 animals dermally exposed for 24 hours (occulsive dressing) at 2000 mg/kg-bw during this study.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item was determined to be non-toxic by the dermal route up to a concentration of 2000 mg/kg-bw.
- Executive summary:
In a GLP guideline study conducted according to OECD 402 with 5 male and 5 female young Wister rats exposed to the test substance at 2000 mg/kg-bw for 24 hours under an occlusive dressing to assess the potential dermal toxicity, no clinical signs, changes in body weight, mortality, or gross pathological findings were noted in any of the animals during the exposure period or 14 day observation period. As such, the substance does not meet the criteria for acute toxicity by the dermal route.
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