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EC number: 214-527-0 | CAS number: 1141-38-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 26, 1981 (Animal Receipt) to May 22, 1981 (Final Report)
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Remarks:
- At the time the study was performed, it followed Proposed Guidelines for Registering Pesticides in te US; Haard Evaluation: Humans and Domestic Animals. Primary Irritation Study. 40 CFR Part 163.81-4
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-4 (Acute Eye Irritation)
- Version / remarks:
- At the time the study was performed, the guideline had not been officially accepted (i.e., Proposed Guideline)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- Study was performed before USEPA GLP guidelines. Study was fully documented and followed SOPs and published literature
Test material
- Reference substance name:
- Naphthalene-2,6-dicarboxylic acid
- EC Number:
- 214-527-0
- EC Name:
- Naphthalene-2,6-dicarboxylic acid
- Cas Number:
- 1141-38-4
- Molecular formula:
- C12H8O4
- IUPAC Name:
- naphthalene-2,6-dicarboxylic acid
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- Very fine white powder, supplied by Celanese corporation. Storage at room temperature.
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- New Zealand White albino rabbits were obtained from Penn Dutch Laboratory Animls in Denver, Pennsylvania, USA. Nine animals were received as young adults weighing between 2.3 and 3.2 kg. The animlas were acclimated for 18 days before treatment.
All animlas were checked for viability twice daily during the equilibration period. Prior to assignment to study, all animals were examined to ascertain suitability for study. Rabbits were individually housed in suspended, stainless steeel, cages. Temperature as monitored twice daily, and ranged from 63-66 degrees farenheight. Humidity was also monitored daily and the animals were on a 12 hr light, 12 hr dark light cycle. Food was Purina Rabbit Chow, fed ad libitum. Animals were provided municipal water (Elizabethtown Water Co.) ad libitum via automatic watering system. Animls were identified with a monel ear tag bearing a unique number.
Test system
- Amount / concentration applied:
- 0.1 cc of the test material was introduced into the lower conjuctival sac of the right eye of each animal.
- Duration of treatment / exposure:
- The upper and lower eye lids were held together for one second prior to relasing to prevent loss of material. The contralateral eye served as the control. The treated and control eyes of six animals remained unwashed. Twenty seconds after the test substance was administered, both eyes of the remaining three animals were rinsed for one minute with lukewarm water.
- Observation period (in vivo):
- Animlals were were checked twice daily, for general signs of toxicity. They eyes were checked at intervals of approximately 24, 48, and 72 hours and 4 and 7 days after treatment. If there were no signs of irritaiton on Day 7, no aditional observations were made.
- Details on study design:
- At each interval the treated and control eyes were examined and scored for occular reactions according to the Draize scale. Fluorescein dye was used to confirm the presence or absence of corneal ulceration in treated eyes starting wtih the 24 hour observation and at each subsequent observation until there was no stain retention for two observations. Unusual effects, such as pannus, blistering of the conjunctiva, ulceration and other effects indicative of corrosive action were also noted when present.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- fully reversible within: 48 hr
- Irritation parameter:
- overall irritation score
- Basis:
- animal #2
- Time point:
- 24 h
- Score:
- 4
- Reversibility:
- fully reversible within: 72 hr
- Irritation parameter:
- overall irritation score
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- fully reversible within: 48
- Irritation parameter:
- overall irritation score
- Basis:
- animal #4
- Time point:
- 24 h
- Score:
- 4
- Reversibility:
- fully reversible within: 72 hr
- Irritation parameter:
- overall irritation score
- Basis:
- animal #5
- Time point:
- 24 h
- Score:
- 0
- Irritation parameter:
- overall irritation score
- Basis:
- animal #6
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- fully reversible within: 48
- Irritation parameter:
- overall irritation score
- Basis:
- animal: 7
- Remarks:
- washed eye
- Time point:
- 24 h
- Score:
- 0
- Irritation parameter:
- overall irritation score
- Basis:
- animal: 8, washed eye
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- fully reversible within: 48 hr
- Irritation parameter:
- overall irritation score
- Basis:
- animal: 9, washed eye
- Time point:
- 24 h
- Score:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Only slight signs of conjunctival redness and/or chemosis at 24 and 48 hrs
- Executive summary:
The only signs of occular irritation were slight conjunctival redness and/or chemosis at 24 and/or 48 hrs in five of six animals with unwashed eyes and in one of three animals with washed eyes. Three animals showed no evidence of ocular irritation. No positive scores were exhibited by any animal and all animals were free of signs of ocular irritation within 72 hrs after administration of 2,4-naphthalene dicarboxylic acid.
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