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EC number: 441-520-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 September 1998 to 24 December 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: Japanese Industrial Standard (JIS K 0102-1993-71) Testing methods for industrial waste water, Acute toxicity test with fish
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- yes
- Remarks:
- HCO-40
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method:
Test material supplied by the sponsor and HCO-40 (40 times amount of the test material) were dissolved with acetone. After acetone was evaporated from the solution, ion-exchanged water was added to the mixture to prepare 1000 mg/L stock solution. - Test organisms (species):
- Oryzias latipes
- Details on test organisms:
- TEST ORGANISM
- Common name: Orange-red killifish
- The fish were checked visually in the receiving and those demonstrating any abnormalities were removed. The fish were reared for 13 days in a flow through system following an external disinfection.
- Length at study initiation: average 3.0 cm
- Weight at study initiation: average 0.26 g
ACCLIMATION
- After rearing, the fish were transferred to an acclimatising aquarium and acclimatised there after the second external disinfection. The fish those
demonstrating any abnormality were removed and reared for 14 days in a flow through system at the temperature of 25 + 2°C. The fish were checked for health conditions and reared another 62 days after the external disinfection. - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 117 mg/L (Ca, Mg)
- Test temperature:
- 25 ± 2°C
- pH:
- At initial exposure: 7.9
At termination of exposure: 7.6 - Dissolved oxygen:
- At initial exposure: 8.1 mg/L
At termination of exposure: 7.4 mg/L - Nominal and measured concentrations:
- Nominal: 250 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: Round glass vessel
- Material, size, headspace, fill volume: 4 L
- Renewal rate of test solution (frequency/flow rate): Renewal of test water, at every 8 - 16 hrs
- No. of organisms per concentration: 10
- No. of organisms per control: 10
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Underground water from the premises of the testing laboratory was used for the test. The dilution water for test was taken out on 3 August 1998, and it was analysed and measured (once every six months in this laboratory). It was confirmed that the dilution water met the ministerial ordinance of the Ministry of Health and Welfare (December 21, 1992), water quality criteria for fisheries (Shadanhozin Nihon Suisansigen Hogokyokai, March 1983), and OECD Guidelines for Testing of Chemicals 210, Fish, Early-life Stage Toxicity Test (July 17, 1992). - Reference substance (positive control):
- not specified
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- >= 250 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Reported statistics and error estimates:
- The 48-hour LC50 was estimated by Doudoroff method.
- Sublethal observations / clinical signs:
Table 1: Cumulative Mortality
Concentration (mg/L)
Cumulative Mortality (%)
2 hours
24 hours
48 hours
Control
-
0
0
250
-
0
0
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Under the conditions of this study, the 48 hour LC50 value was ≥ 250 mg/L.
- Executive summary:
The acute toxicity of the test material to fish was investigated in accordance with Japanese Industrial Standard (JIS K 0102-1993-71.) titled "Testing methods for industrial waste water, Acute toxicity test with fish". The testing was performed under GLP conditions.
Oryzias Iatipes (Orange-red killifish) were exposed to the test material for 48 hours in a semi-static test system. Ten fish were treated at 250 mg/L and ten fish were used as a control group.
The 48-hr LC50 value was estimated by Doudoroff method. No mortality was observed in the test material treated or the control group during the study.
Under the conditions of this study, the 48 hour LC50 value was ≥ 250 mg/L.
Reference
Description of key information
Under the conditions of the study, the 48 hour LC50 value was ≥ 250 mg/L.
Key value for chemical safety assessment
Additional information
The acute toxicity of the test material to fish was investigated in accordance with Japanese Industrial Standard (JIS K 0102-1993-71.) titled "Testing methods for industrial waste water, Acute toxicity test with fish". The testing was performed under GLP conditions.
Oryzias Iatipes (Orange-red killifish) were exposed to the test material for 48 hours in a semi-static test system. Ten fish were treated at 250 mg/L and ten fish were used as a control group.
The 48-hr LC50 value was estimated by Doudoroff method. No mortality was observed in the test material treated or the control group during the study.
Under the conditions of the study, the 48 hour LC50 value was ≥ 250 mg/L.
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