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Diss Factsheets
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EC number: 203-026-2 | CAS number: 102-36-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
General Information
- Name:
- 1272/2008 CLP Henkel Registration (AOT 3, H301; AIT 2, H330; Skin Sens. 1A, H317; Eye Dam. 1, H318; Resp. Sens 1, H334; STOT SE3, H335; H400 Ma=1; H410 Mc=10); SPEC; AM <= 100%
- Implementation:
- EU
- Remarks:
HENKEL REGISTERED SUBSTANCE
CS 157799; SPEC -
Data Tox, Reference:
- C&L based on study results;
- Resp. sensitisation based on EJ (ASS 1800110 -1):
The unique feature common to all isocyanates is that they contain N=C=O (isocyanate) functional groups attached to an aromatic or aliphatic parent compound. Isocyanates can cause skin sensitization, asthma, skin or mucous membrane irritation, and, rarely hypersensitivity pneumonitis. However, the most common adverse health outcome associated with isocyanate exposure is asthma due to sensitization.
Evidence exists that respiratory sensitization is triggered by dermal induction. In addition, vice versa, topical contact hypersensitivity was observed after previous induction by inhalation. The Technical Guidance Document (TGD) on information requirements for REACH (R.7a; page 256ff) proposes that, in the absence of specific health effects data, only diisocyanates that also meet the criteria for classification for skin sensitization are presumed to be respiratory sensitizers. It is assumed that this recommendation also applies to monoisocyanates such as 3,4-dichlorophenyl isocyanate. 3,4-Dichlorophenyl isocyanate is a strong skin sensitizer in the Magnusson & Kligman Test. It is therefore concluded that 3,4-dichlorophenyl isocyanate is contributing to the development of isocyanate asthma, presumably by inducing systemic sensitization.
According to the recent background document to the opinion on the Annex XV dossier proposing restrictions on diisocyanates (https://echa.europa.eu/documents/10162/ddc6108d-a33e-3087-6a6a-8754783c2aa8) RAC considers that for monoisocyanates, based on indirect evidence from humans and animals referenced in that document, the risk of respiratory sensitization in humans cannot be excluded.
The German Commission for Investigation of Health Hazards of Chemical Compounds in the Work Area also concluded (see p. 201:https://onlinelibrary.wiley.com/doi/pdf/10.1002/9783527812127.ch4) that sensitizing effects of monoisocyanates on the respiratory tract cannot be ruled out. However, data for the diisocyanates, which are assessed as potent respiratory allergens, would not justify classifying monoisocyanates as substances causing airway sensitization solely in analogy; an evaluation of the individual case is necessary.
Information on the individual structural analogues phenyl isocyanate (CAS 103-71-9) and 4-chlorophenyl isocyanate (CAS 104-12-1) support the conclusion that 3,4-dichlorophenyl isocyanate may pose a respiratory health hazard. Workers exposed to phenyl isocyanate showed specific IgE for isocyanate-albumin conjugates. These workers also developed asthmatic symptoms (BG Chemie, Phenylisocyanate Nr. 198, 1997). Furthermore, phenyl isocyanate is classified by German Commission for Investigation of Health Hazards of Chemical Compounds in the Work Area as respiratory sensitizer. 4-Chlorophenyl isocyanate, a close analogue to 3,4-dichlorophenyl isocyanate, is not skin-sensitizing when tested in a split adjuvant test in guinea pigs. However, 4-chlorophenyl isocyanate is classified as respiratory sensitizer according to CLP, Annex VI.
Taking all available information into account 3,4-dichlorophenyl isocyanate is classified as respiratory sensitizer in a Weight of Evidence assessment.
Data Eco, Reference:
The environmental classification is based on ecotoxicity data for the hydrolysis product 3,4 -Dichlorophenylamine against freshwater invertebrates.
Related composition
- Related composition:
- 3,4-Dichlorophenyl isocyanate
- 3,4-Dichlorophenyl isocyanate
Classificationopen allclose all
Explosives
- Reason for no classification:
- data conclusive but not sufficient for classification
Flammable gases and chemically unstable gases
- Reason for no classification:
- data lacking
Aerosols
- Reason for no classification:
- data lacking
Oxidising gases
- Reason for no classification:
- data lacking
Gases under pressure
- Reason for no classification:
- data lacking
Flammable liquids
- Reason for no classification:
- data lacking
Flammable solids
- Reason for no classification:
- data conclusive but not sufficient for classification
Self-reactive substances and mixtures
- Reason for no classification:
- data lacking
Pyrophoric liquids
- Reason for no classification:
- data lacking
Pyrophoric solids
- Reason for no classification:
- data conclusive but not sufficient for classification
Self-heating substances and mixtures
- Reason for no classification:
- data lacking
Substances and mixtures which in contact with water emit flammable gases
- Reason for no classification:
- data conclusive but not sufficient for classification
Oxidising liquids
- Reason for no classification:
- data lacking
Oxidising solids
- Reason for no classification:
- data conclusive but not sufficient for classification
Organic peroxides
- Reason for no classification:
- data lacking
Corrosive to metals
- Reason for no classification:
- data lacking
Desensitized explosives
- Reason for no classification:
- data lacking
Acute toxicity - oral
- Hazard category:
- Acute Tox. 3
- Hazard statement:
- H301: Toxic if swallowed.
Acute toxicity - dermal
- Reason for no classification:
- data lacking
Acute toxicity - inhalation
- Hazard category:
- Acute Tox. 2
- Hazard statement:
- H330: Fatal if inhaled.
Skin corrosion / irritation
- Reason for no classification:
- data conclusive but not sufficient for classification
Serious eye damage / eye irritation
- Hazard category:
- Eye Damage 1
- Hazard statement:
- H318: Causes serious eye damage.
Respiratory sensitisation
- Hazard category:
- Resp. Sens. 1
- Hazard statement:
- H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Skin sensitisation
- Hazard category:
- Skin Sens. 1A
- Hazard statement:
- H317: May cause an allergic skin reaction.
Aspiration hazard
- Reason for no classification:
- data lacking
Reproductive toxicity
- Reason for no classification:
- data lacking
Effects on or via lactation
- Reason for no classification:
- data lacking
Germ cell mutagenicity
- Reason for no classification:
- data conclusive but not sufficient for classification
Carcinogenicity
- Reason for no classification:
- data lacking
1. Specific target organ toxicity - single (STOT-SE)
- Hazard category:
- STOT Single Exp. 3
- Hazard statement:
- H335: May cause respiratory irritation.
- Affected organs:
- other: resp. tract
- Route of exposure:
- inhalation
1. Specific target organ toxicity - repeated (STOT-RE)
- Reason for no classification:
- data lacking
Hazardous to the aquatic environment (acute / short-term)
- Hazard category:
- Aquatic Acute 1
- Hazard statement:
- H400: Very toxic to aquatic life.
Hazardous to the aquatic environment (long-term)
- Hazard category:
- Aquatic Chronic 1
- Hazard statement:
- H410: Very toxic to aquatic life with long lasting effects.
- M-Factor acute:
- 1
- M-Factor chronic:
- 10
Hazardous to the ozone layer
- Reason for no classification:
- data lacking
Labelling
- Signal word:
- Danger
Hazard pictogram
- GHS09: environment
- GHS05: corrosion
- GHS06: skull and crossbones
Hazard statements
- H400: Very toxic to aquatic life.
- H410: Very toxic to aquatic life with long lasting effects.
- H301: Toxic if swallowed.
- H317: May cause an allergic skin reaction.
- H318: Causes serious eye damage.
- H330: Fatal if inhaled.
- H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled.
- H335: May cause respiratory irritation.
Notes
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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