Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 430-280-3 | CAS number: 844491-96-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From November 1997 to April 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- The concentration control analytics were performed with the test substance solutions of the following nominal concentrations: 100, 12.5, 0 mg/L. At the start of the test (after 0 hours) samples from vessels without daphnids were analyzed. At the end of the test (after 48 h) samples from vessels with and without daphnids were analyzed.
- Vehicle:
- no
- Details on test solutions:
- Preparation of the stock solution and dilution:
The test substance was stirred in M4 medium for about 10 minutes at approximately 20 ± 1 °C. The nominal concentration of the stock solution eluate was 100 mg/L.
By dilution of this stock solution with M4 medium the following nominal concentrations were prepared:
100, 50, 25, 12.5 mg/L. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia magna STRAUS 1820. Supplier: Institut National de Recherche Chimique Appliquee, France.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 20.9 - 21.7 °C
- pH:
- pH value: 7.9 - 8.0
- Dissolved oxygen:
- 7.9 - 8.6 mg/L
- Conductivity:
- Conductivity: 550 - 650 µS/cm
- Nominal and measured concentrations:
- concentration range: 12.5 - 100 mg/L (dilution factor 2).
- Details on test conditions:
- Test volume: 10 mL
Loading (animals/mL): 0.5
Number of animals per vessel: 5
Total number of animals/conc.: 20
Number of replicates per concentration and per control: 4
Age of the animals: 2-24 hours
Age of stock animals: 2-4 weeks
Illumination: artificial light, type warm white (eg. OSRAM L58 W31); day: night rhythm 16:8
Check of the study and recording: visually after 0, 3, 6, 24 and 48 h - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Validity criteria were fulfilled:
- In the control the immobilization was ≤ 10 %
- In the control no Daphnids were captured in a surface film
- The O2 concentration was in all tested replicates .3mg/L
- The EC50(24h) of the control substance potassium dichromate was 1.25 mg/L - Results with reference substance (positive control):
- The EC50(24h) of the control substance potassium dichromate was 1.25 mg/L
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the study conditions, the nominal 48-h EC50 was determined to be >100 mg/L.
- Executive summary:
A study was conducted to determine toxicity of the test substance to the water flea (Daphnia magna) according to EU Method C.2, in compliance with GLP. For each test concentration, 20 Daphnia were exposed to the test substance for 48 h in a static test system. After 24 and 48 h, the immobilised Daphnia were counted. The substance was tested in the range of 12.5 to 100 mg/L. M4 medium served as negative control and potassium dichromate as positive control. The concentrations were analytically confirmed by spectrophotometry at 532 nm. Control analytics were performed with the test substance solutions of the following nominal concentrations: 100, 12.5 and 0 mg/L. At test start, samples from vessels without Daphnids were analysed. At the end of the test (after 48 h), samples from vessels with and without Daphnids were analysed. No toxicity was observed in any of the groups. The concentrations measured were in accordance with the expected nominal values. Under the study conditions, the nominal 48 hEC50 was > 100 mg/L and the 48 h NOEC was 100 mg/L (Maish, 1998).
Reference
Description of key information
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.