Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 500-301-1 | CAS number: 111870-68-9 1 - 6.5 moles propoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 January 2018 to 19 January 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- no analytics were performed because it was not possible to develop a suitable analytical method
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Remarks:
- it was imposible to develop a suitable analytical method
- Vehicle:
- yes
- Details on test solutions:
- A primary stock concentrate of the substance, with a nominal concentration of 10 g/L, was prepared by weighing a nominal 0.1 g of test substance (actual weight: 0.10000 g) into a 10 mL volumetric flask and making up to volume with tetrahydrofuran (THF). The stock was then manually shaken to mix. The resultant stock was observed to be clear and colourless and was used to prepare the test solutions.
Total amount of THF present in the test solutions 100 ug/L. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphmia magna
- Source: laboratory cultures held at Scymaris.
- Age of parental stock (mean and range, SD): 22 ± 1 days (daphnids in test < 24 h)
- Feeding during test: none
ACCLIMATION
- Stock conditions (same as test or not): yes
- Type and amount of food: mixed algae diet of Chlorella vulgaris, strain CCAP 211/12 and Pseudokirchneriella subcapitata, strain CCAP 278/4
- Feeding frequency: daily ad libitum
- Health during acclimation: no evidence of diease before test:
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 248.7 as CaCO2
- Test temperature:
- 19.1-20.2 ˚C
- pH:
- 7.76-8.01
- Dissolved oxygen:
- 9.05-9.35 mg/L
- Nominal and measured concentrations:
- nominal: 0.0625, 0.125, 0.25, 0.5 and 1.0 mg/L (maximum based on solubility)
- Details on test conditions:
- TEST SYSTEM
- Test vessel: Glass beakers of 250 mL
- Type (delete if not applicable):closed
- Fill volume: 200 mL
- Aeration: no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- No. of vessels per vehicle control (replicates): 4
TEST MEDIUM / WATER PARAMETERS: The reconstituted water medium used for testing (and maintenance of stock cultures) was Elendt's M4 D. magna medium
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16/8
EFFECT PARAMETERS MEASURED : immobilisation at 24 and 48 h
VEHICLE CONTROL PERFORMED: yes
RANGE-FINDING STUDY: highest concentration limited by solubility in water
concentrations tested : 0.0625, 0.125, 0.25, 0.5 and 1.0 mg/L (max THF 100 ug/L)
results: immobility: 0, 0, 0, 20 and 20% at 0.0625, 0.125, 0.25, 0.5 and 1.0 mg/L
behaviour: Daphnia in 0.25, 0.5 and 1.0 mg/L test concentrations showed reduced movement compared to controls. At 0.5 and 1.0 mg/L 4/10 daphnids were at the surface
- Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Daphnids in the 0.5 and 1.0 mg/L test concentrations were observed as less active compared to the controls.
At the 48 hour time point, the two immobile daphnids in 0.5 mg/L replicates A and D were observed to be still alive as they were twitching. The immobile daphnid in 0.5 mg/L replicate C was on the surface of the solution. - Validity criteria fulfilled:
- yes
- Conclusions:
- The EC50 for Daphnia magna is > 1.0 mg/L
- Executive summary:
Due to the low solubility of the substance, a 1 mg/L test concentration was selected as the highest concentration based on a non-GLP range finding study. The test substance was dosed to the media via a solvent carrier (tetrahydrofuran (THF)) to assist in dosing the test compound. The concentration of solvent used in all exposure solutions with the exception of the control was 100 µL/L.
Daphnids were exposed during 48 h (static test) to control, Solvent Control and nominal concentrations of 0.0625, 0.125, 0.25, 0.5 and 1.0 mg/L. No confirmatory analysis of the test solutions was performed due to lack of an analytical method.
The EC50 is >1.0 mg/L. Based on immobility compared to the control (p <0.05) the 48h NOEC was determined to be 1.0 mg/L. Immobility in the 0.5 mg/L test concentration was significantly different (p <0.05) from the control. However, as immobility in the 1.0 mg/L test concentration was not significantly different (p <0.05) from the control, the NOEC was not affected.
Reference
Daphnia magna response
Time (hour) |
Nominal concentration of test substance
(mg/L) |
Number immobilised per replicate |
Total number tested |
Total number immobilised |
Percentage immobilised |
|||
A |
B |
C |
D |
|||||
24 |
Control |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
Solvent Control |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
|
0.0625 |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
|
0.125 |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
|
0.25 |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
|
0.5 |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
|
1.0 |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
|
48 |
Control |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
Solvent Control |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
|
0.0625 |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
|
0.125 |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
|
0.25 |
0 |
1 |
0 |
0 |
20 |
1 |
5 |
|
0.5 |
1 |
1 |
1 |
1 |
20 |
4 |
20 * |
|
1.0 |
1 |
2 |
0 |
0 |
20 |
3 |
15 |
* Significant difference (p <0.05) from the control. LOEC value not affected, see section 5.1.
Description of key information
Daphnids were exposed during 48 h (static test) to control and nominal concentrations of 6.25, 12.5, 25, 50 and 100 mg/L (mean measured 0.35, 0.58, 3.9, 6.8 and 11 mg/L) of the substance. At study start solutions (WAF) at and above 12.5 mg/L showed haziness/cloudiness that could be related to the increasing concentrations.
The EC50 is 6.8 mg/L. Based on immobility compared to the control (p <0.05) the 48 hour NOEC was determined to be 0.58 mg/L and the Lowest Observed Effect Concentration (LOEC) was 3.9 mg/L. There was no immobility observed in the dilution water control. At 24 and 48 hours, all mobile D. magna in the 50 and 100 mg/L nominal loading concentrations were slow moving and at the bottom of the test vessels when compared to the controls. At 24 and 48 hours the solutions appeared similar to 0 hours test solution observations with addition of a residue on the surface in a dose-dependent quantity. The residue appears to be very fine particulate and/or droplets spread over the surface in patches that connect together.
Daphnids were exposed during 48 h (static test) to control, solvent control and nominal concentrations of 0.0625, 0.125, 0.25, 0.5 and 1.0 mg/L of a structural analogue of the substance. No confirmatory analysis of the test solutions was performed due to lack of an analytical method.
The EC50 is >1.0 mg/L. Based on immobility compared to the control (p <0.05) the 48h NOEC was determined to be 1.0 mg/L. Immobility in the 0.5 mg/L test concentration was significantly different (p <0.05) from the control. However, as immobility in the 1.0 mg/L test concentration was not significantly different (p <0.05) from the control, the NOEC was not affected.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 6.8 mg/L
Additional information
The results of the daphnia studies with Castor oil, hydrogenated, propoxylated and Castor oil, hydrogenated, ethoxylated
are very similar and indicative for no or low toxicity at the solubility level. These data support the read-across hypothesis as depicted in section 13 in detail.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.